| 4. Round | 28/08/2021 | Rot Weiss Ahlen | - | Fortuna Düsseldorf II | 1:1 | ||||
| 6. Round | 11/09/2021 | SV 19 Straelen | - | Fortuna Düsseldorf II | 1:1 |  |
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| 7. Round | 15/09/2021 | Fortuna Düsseldorf II | - | Wuppertaler SV | 1:2 | ||||
| 8. Round | 19/09/2021 | Fortuna Köln | - | Fortuna Düsseldorf II | 0:0 | ||||
| 9. Round | 25/09/2021 | Bonner SC | - | Fortuna Düsseldorf II | 0:3 | ||||
| 10. Round | 02/10/2021 | Fortuna Düsseldorf II | - | VfB Homberg | 4:0 | ||||
| 12. Round | 15/10/2021 | Fortuna Düsseldorf II | - | FC Schalke 04 II | 5:1 | ||||
| 13. Round | 23/10/2021 | SV Lippstadt 08 | - | Fortuna Düsseldorf II | 5:2 |  |
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| 14. Round | 31/10/2021 | Fortuna Düsseldorf II | - | Rot-Weiß Oberhausen | 2:2 | ||||
| 15. Round | 06/11/2021 | KFC Uerdingen 05 | - | Fortuna Düsseldorf II | 1:1 | ||||
| 17. Round | 21/11/2021 | 1. FC Köln II | - | Fortuna Düsseldorf II | 1:1 |
Germany