| 1. Round | 16/07/2021 | TSV 1896 Rain | - | SpVgg Bayreuth | 0:4 | ||||
| 2. Round | 24/07/2021 | 1. FC Schweinfurt 05 | - | TSV 1896 Rain | 5:1 |  |
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| 3. Round | 27/07/2021 | TSV 1896 Rain | - | Viktoria Aschaffenburg | 0:2 | ||||
| 4. Round | 30/07/2021 | TSV Buchbach | - | TSV 1896 Rain | 4:0 | ||||
| 5. Round | 03/08/2021 | FV Illertissen | - | TSV 1896 Rain | 1:1 | ||||
| 6. Round | 07/08/2021 | TSV 1896 Rain | - | SpVgg Greuther Fürth II | 2:2 | |
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| 7. Round | 14/08/2021 | TSV Aubstadt | - | TSV 1896 Rain | 4:0 | |
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| 8. Round | 17/08/2021 | TSV 1896 Rain | - | Wacker Burghausen | 0:4 | ||||
| 9. Round | 21/08/2021 | 1. FC Nürnberg II | - | TSV 1896 Rain | 0:1 | ||||
| 10. Round | 28/08/2021 | TSV 1896 Rain | - | FC Augsburg II | 2:4 | ||||
| 11. Round | 31/08/2021 | SV Heimstetten | - | TSV 1896 Rain | 3:1 | |
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| 13. Round | 11/09/2021 | VfB Eichstätt | - | TSV 1896 Rain | 0:1 | ||||
| 12. Round | 14/09/2021 | TSV 1896 Rain | - | SC Eltersdorf | 0:2 | ||||
| 14. Round | 18/09/2021 | TSV 1896 Rain | - | FC Memmingen | 0:2 | ||||
| 33. Round | 16/04/2022 | FC Memmingen | - | TSV 1896 Rain | 0:0 | ||||
| 38. Round | 21/05/2022 | TSV 1896 Rain | - | TSV 1860 Rosenheim | 5:0 |
Germany