| 5. Round | 28/09/2021 | SC Wiedenbrück | - | 1. FC Köln II | 2:0 | ||||
| 13. Round | 23/10/2021 | SC Wiedenbrück | - | SV 19 Straelen | 2:0 | ||||
| 15. Round | 06/11/2021 | SC Wiedenbrück | - | Fortuna Köln | 0:1 | ||||
| 8. Round | 10/11/2021 | Sportfreunde Lotte | - | SC Wiedenbrück | 0:2 | ||||
| 17. Round | 20/11/2021 | SC Wiedenbrück | - | VfB Homberg | 3:0 |
Germany