| 11. Round | 09/10/2022 | VfR Aalen | - | 1. FSV Mainz 05 II | 0:2 |  |
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| 14. Round | 30/10/2022 | 1. FSV Mainz 05 II | - | Hessen Kassel | 3:1 | |
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| 15. Round | 05/11/2022 | Kickers Offenbach | - | 1. FSV Mainz 05 II | 1:1 |  |
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| 17. Round | 20/11/2022 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 4:1 | ||||
| 18. Round | 26/11/2022 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 4:1 | ||||
| 19. Round | 03/12/2022 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 1:1 | ||||
| 20. Round | 10/12/2022 | 1. FSV Mainz 05 II | - | SG Barockstadt Fulda-Lehnerz | 1:1 | ||||
| 21. Round | 04/03/2023 | Bahlinger SC | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 28. Round | 15/04/2023 | 1. FSV Mainz 05 II | - | VfR Aalen | 4:1 | ||||
| 24. Round | 18/04/2023 | 1. FSV Mainz 05 II | - | 1899 Hoffenheim II | 1:2 | ||||
| 29. Round | 22/04/2023 | TSG Balingen | - | 1. FSV Mainz 05 II | 1:1 | |
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| 30. Round | 30/04/2023 | 1. FSV Mainz 05 II | - | FC 08 Homburg | 2:2 | ||||
| 31. Round | 06/05/2023 | Hessen Kassel | - | 1. FSV Mainz 05 II | 1:0 | ||||
| 32. Round | 13/05/2023 | 1. FSV Mainz 05 II | - | Kickers Offenbach | 2:0 | ||||
| 33. Round | 20/05/2023 | FC-Astoria Walldorf | - | 1. FSV Mainz 05 II | 0:1 | ||||
| 34. Round | 26/05/2023 | 1. FSV Mainz 05 II | - | VfB Stuttgart II | 0:1 |
Germany