| 1. Round | 10/04/2022 | 1. FC Kaan-Marienborn | - | Westfalia Rhynern | 3:2 | ||||
| 2. Round | 18/04/2022 | SG Wattenscheid 09 | - | 1. FC Kaan-Marienborn | 1:1 | ||||
| 4. Round | 01/05/2022 | ASC 09 Dortmund | - | 1. FC Kaan-Marienborn | 2:2 | ||||
| 5. Round | 08/05/2022 | 1. FC Kaan-Marienborn | - | Sportfreunde Siegen | 4:0 |  |
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| 6. Round | 15/05/2022 | TuS Erndtebrück | - | 1. FC Kaan-Marienborn | 1:6 | |
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| 7. Round | 22/05/2022 | 1. FC Kaan-Marienborn | - | FCE Rheine | 2:2 | ||||
| 3. Round | 25/05/2022 | 1. FC Kaan-Marienborn | - | SC Paderborn 07 II | 4:2 | |
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| 8. Round | 29/05/2022 | SV Schermbeck | - | 1. FC Kaan-Marienborn | 1:3 | ||||
| 9. Round | 06/06/2022 | 1. FC Kaan-Marienborn | - | FC Gütersloh | 4:2 |
Japan