| 1. Round | 10/04/2022 | TuS Erndtebrück | - | ASC 09 Dortmund | 2:0 |  |
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| 2. Round | 18/04/2022 | Sportfreunde Siegen | - | TuS Erndtebrück | 1:0 | ||||
| 3. Round | 24/04/2022 | FC Gütersloh | - | TuS Erndtebrück | 5:3 | |
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| 4. Round | 01/05/2022 | TuS Erndtebrück | - | FCE Rheine | 2:1 | ||||
| 5. Round | 07/05/2022 | SV Schermbeck | - | TuS Erndtebrück | 0:1 | ||||
| 6. Round | 15/05/2022 | TuS Erndtebrück | - | 1. FC Kaan-Marienborn | 1:6 | ||||
| 7. Round | 22/05/2022 | Westfalia Rhynern | - | TuS Erndtebrück | 5:1 | ||||
| 8. Round | 29/05/2022 | TuS Erndtebrück | - | SG Wattenscheid 09 | 1:2 | |
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| 9. Round | 06/06/2022 | SC Paderborn 07 II | - | TuS Erndtebrück | 3:1 |
Germany