| 1. Round | 08/08/2021 | VFC Plauen | - | Union Sandersdorf | 0:4 | ||||
| 2. Round | 14/08/2021 | FSV Martinroda | - | VFC Plauen | 0:2 | ||||
| 3. Round | 18/08/2021 | VFC Plauen | - | Blau-Weiß Zorbau | 4:1 | ||||
| 4. Round | 21/08/2021 | Bischofswerdaer FV | - | VFC Plauen | 2:2 | ||||
| 5. Round | 29/08/2021 | VFC Plauen | - | FC Einheit Rudolstadt | 2:0 | ||||
| 6. Round | 12/09/2021 | Wacker Nordhausen | - | VFC Plauen | 0:2 | ||||
| 7. Round | 18/09/2021 | VFC Plauen | - | VfL Halle 96 | 1:1 | ||||
| 8. Round | 26/09/2021 | 1. FC Merseburg | - | VFC Plauen | annull. | ||||
| 9. Round | 02/10/2021 | VFC Plauen | - | FC An der Fahner Höhe | 2:0 |
Germany