| 1. Round | 15/08/2021 | FSV Frankfurt [Youth B] | - | Stuttgarter Kickers [Youth B] | 2:1 | ||||
| 2. Round | 21/08/2021 | FC Augsburg [Youth B] | - | FSV Frankfurt [Youth B] | 0:2 | ||||
| 4. Round | 11/09/2021 | FC Ingolstadt 04 [Youth B] | - | FSV Frankfurt [Youth B] | 2:0 | ||||
| 5. Round | 19/09/2021 | FSV Frankfurt [Youth B] | - | SSV Reutlingen [Youth B] | 2:2 | ||||
| 6. Round | 25/09/2021 | SC Freiburg [Youth B] | - | FSV Frankfurt [Youth B] | 3:1 | ||||
| 9. Round | 31/10/2021 | FSV Frankfurt [Youth B] | - | 1. FC Kaiserslautern [Youth B] | 0:0 | ||||
| 10. Round | 06/11/2021 | 1. FC Heidenheim 1846 [Youth B] | - | FSV Frankfurt [Youth B] | 3:1 |  |
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| 14. Round | 11/12/2021 | SV Wehen Wiesbaden [Youth B] | - | FSV Frankfurt [Youth B] | 2:1 |
Italy