| 1. Round | 08/08/2021 | SV 09 Arnstadt | - | VfL Halle 96 | 1:3 | ||||
| 3. Round | 18/08/2021 | Inter Leipzig | - | VfL Halle 96 | 2:2 |  |
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| 4. Round | 21/08/2021 | VfL Halle 96 | - | Einheit Wernigerode | 0:2 | ||||
| 5. Round | 28/08/2021 | FC Carl Zeiss Jena II | - | VfL Halle 96 | 3:0 | ||||
| 6. Round | 11/09/2021 | VfL Halle 96 | - | VfB 1921 Krieschow | 1:0 | ||||
| 7. Round | 18/09/2021 | VFC Plauen | - | VfL Halle 96 | 1:1 | ||||
| 8. Round | 25/09/2021 | VfL Halle 96 | - | Rot-Weiß Erfurt | 1:1 | ||||
| 9. Round | 02/10/2021 | FC Grimma | - | VfL Halle 96 | 0:3 | |
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| 10. Round | 16/10/2021 | VfL Halle 96 | - | Union Sandersdorf | 2:2 | ||||
| 11. Round | 23/10/2021 | FSV Martinroda | - | VfL Halle 96 | 1:2 | ||||
| 13. Round | 06/11/2021 | Bischofswerdaer FV | - | VfL Halle 96 | 1:3 | ||||
| 19. Round | 13/11/2021 | VfL Halle 96 | - | FC Oberlausitz | 3:0 | ||||
| 14. Round | 20/11/2021 | VfL Halle 96 | - | FC Einheit Rudolstadt | 3:1 |
Germany