| 1. Round | 08/08/2021 | Rot-Weiß Erfurt | - | FC Grimma | 3:2 | ||||
| 2. Round | 15/08/2021 | FC Grimma | - | FSV Budissa Bautzen | 2:3 | ||||
| 3. Round | 18/08/2021 | FC Grimma | - | Union Sandersdorf | 1:3 | ||||
| 4. Round | 22/08/2021 | FSV Martinroda | - | FC Grimma | 1:2 |  |
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| 5. Round | 28/08/2021 | FC Grimma | - | Blau-Weiß Zorbau | 2:2 | ||||
| 6. Round | 11/09/2021 | Bischofswerdaer FV | - | FC Grimma | 3:1 | ||||
| 7. Round | 19/09/2021 | FC Grimma | - | FC Einheit Rudolstadt | 3:0 | ||||
| 8. Round | 26/09/2021 | Wacker Nordhausen | - | FC Grimma | 3:2 | ||||
| 9. Round | 02/10/2021 | FC Grimma | - | VfL Halle 96 | 0:3 | ||||
| 21. Round | 02/04/2022 | FSV Budissa Bautzen | - | FC Grimma | 2:0 | ||||
| 32. Round | 12/06/2022 | SV 09 Arnstadt | - | FC Grimma | 4:1 |
Germany