| 5. Round | 03/09/2021 | 1. FSV Mainz 05 II | - | VfB Stuttgart II | 2:4 | ||||
| 7. Round | 15/09/2021 | FK Pirmasens | - | VfB Stuttgart II | 2:3 | ||||
| 12. Round | 09/10/2021 | VfB Stuttgart II | - | TSV Steinbach Haiger | 0:0 | ||||
| 15. Round | 26/10/2021 | VfB Stuttgart II | - | FSV Frankfurt | 1:1 | ||||
| 24. Round | 12/02/2022 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 27. Round | 05/03/2022 | Bahlinger SC | - | VfB Stuttgart II | 0:0 | ||||
| 32. Round | 06/04/2022 | VfB Stuttgart II | - | SG Sonnenhof Großaspach | 0:1 | ||||
| 30. Round | 13/04/2022 | VfB Stuttgart II | - | FC Gießen | 1:0 | ||||
| 34. Round | 16/04/2022 | FSV Frankfurt | - | VfB Stuttgart II | 1:2 |
Germany