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| 26/03/2022 | 13:00 | FC 08 Homburg | - | TSG Balingen | 0:0 (0:0) | |
| 13:00 | FSV Frankfurt | - | VfR Aalen | 0:0 (0:0) | ||
| 13:00 | Kickers Offenbach | - | FK Pirmasens | 3:0 (1:0) | ||
| 13:00 | Rot-Weiß Koblenz | - | 1. FSV Mainz 05 II | 0:0 (0:0) | ||
| 13:00 | SG Sonnenhof Großaspach | - | TSV Steinbach Haiger | 0:2 (0:1) | ||
| 13:00 | SSV Ulm 1846 | - | TSV Schott Mainz | 2:0 (1:0) | ||
| 13:00 | SV 07 Elversberg | - | Bahlinger SC | 3:3 (2:3) | ||
| 13:00 | 1899 Hoffenheim II | - | FC-Astoria Walldorf | 1:0 (0:0) | ||
| 13/04/2022 | 18:00 | VfB Stuttgart II | - | FC Gießen | 1:0 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV 07 Elversberg | 28 | 17 | 7 | 4 | 62:25 | 37 | 58 |
| 2 |
|
SSV Ulm 1846 | 28 | 17 | 7 | 4 | 46:24 | 22 | 58 |
| 3 |
|
Kickers Offenbach | 28 | 18 | 3 | 7 | 50:19 | 31 | 57 |
| 4 |
|
TSV Steinbach Haiger | 28 | 16 | 8 | 4 | 51:29 | 22 | 56 |
| 5 |
|
1. FSV Mainz 05 II | 29 | 17 | 2 | 10 | 44:35 | 9 | 53 |
| 6 |
|
FC 08 Homburg | 29 | 13 | 8 | 8 | 41:38 | 3 | 47 |
| 7 |
|
Bahlinger SC | 28 | 11 | 8 | 9 | 30:30 | 0 | 41 |
| 8 |
|
TSG Balingen | 28 | 11 | 5 | 12 | 38:50 | -12 | 38 |
| 9 |
|
Hessen Kassel | 28 | 9 | 10 | 9 | 33:29 | 4 | 37 |
| 10 |
|
VfB Stuttgart II | 29 | 9 | 7 | 13 | 38:41 | -3 | 34 |
| 11 |
|
FC-Astoria Walldorf | 29 | 9 | 7 | 13 | 40:47 | -7 | 34 |
| 12 |
|
1899 Hoffenheim II | 28 | 8 | 9 | 11 | 39:40 | -1 | 33 |
| 13 |
|
Rot-Weiß Koblenz | 28 | 7 | 11 | 10 | 30:36 | -6 | 32 |
| 14 |
|
VfR Aalen | 28 | 9 | 5 | 14 | 39:51 | -12 | 32 |
| 15 |
|
FSV Frankfurt | 29 | 7 | 10 | 12 | 32:39 | -7 | 31 |
| 16 |
|
SG Sonnenhof Großaspach | 29 | 8 | 5 | 16 | 36:58 | -22 | 29 |
| 17 |
|
FC Gießen | 28 | 7 | 7 | 14 | 26:35 | -9 | 28 |
| 18 |
|
FK Pirmasens | 29 | 6 | 6 | 17 | 23:49 | -26 | 24 |
| 19 |
|
TSV Schott Mainz | 29 | 6 | 5 | 18 | 26:49 | -23 | 23 |
| Promotion | |
| Relegation |
