| 3. Round | 18/08/2021 | Einheit Wernigerode | - | Wacker Nordhausen | 2:2 | ||||
| 4. Round | 22/08/2021 | Wacker Nordhausen | - | FC Carl Zeiss Jena II | 1:3 | ||||
| 5. Round | 28/08/2021 | VfB 1921 Krieschow | - | Wacker Nordhausen | 1:1 | ||||
| 7. Round | 17/09/2021 | Rot-Weiß Erfurt | - | Wacker Nordhausen | 3:0 | ||||
| 8. Round | 26/09/2021 | Wacker Nordhausen | - | FC Grimma | 3:2 |  |
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| 9. Round | 02/10/2021 | Wacker Nordhausen | - | Union Sandersdorf | 1:2 |  |
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| 14. Round | 06/02/2022 | Wacker Nordhausen | - | FSV Budissa Bautzen | 1:4 | ||||
| 15. Round | 13/02/2022 | Wacker Nordhausen | - | VfL Halle 96 | 2:1 | ||||
| 23. Round | 10/04/2022 | FC Carl Zeiss Jena II | - | Wacker Nordhausen | 0:1 | ||||
| 25. Round | 23/04/2022 | VFC Plauen | - | Wacker Nordhausen | 1:1 | ||||
| 26. Round | 29/04/2022 | Wacker Nordhausen | - | Rot-Weiß Erfurt | 0:4 |
Germany