| 1. Round | 07/08/2021 | VfB 1921 Krieschow | - | FSV Martinroda | 3:2 | ||||
| 4. Round | 22/08/2021 | FSV Martinroda | - | FC Grimma | 1:2 | ||||
| 5. Round | 28/08/2021 | Union Sandersdorf | - | FSV Martinroda | 0:0 | ||||
| 6. Round | 11/09/2021 | FSV Martinroda | - | FSV Budissa Bautzen | 2:4 |  |
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| 7. Round | 18/09/2021 | FSV Martinroda | - | Blau-Weiß Zorbau | 3:1 | ||||
| 8. Round | 25/09/2021 | Bischofswerdaer FV | - | FSV Martinroda | 2:1 | ||||
| 9. Round | 29/09/2021 | FSV Martinroda | - | FC Einheit Rudolstadt | 0:2 | ||||
| 11. Round | 23/10/2021 | FSV Martinroda | - | VfL Halle 96 | 1:2 |  |
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| 12. Round | 31/10/2021 | 1. FC Merseburg | - | FSV Martinroda | annull. | ||||
| 13. Round | 13/11/2021 | FSV Martinroda | - | FC An der Fahner Höhe | 2:1 | ||||
| 14. Round | 05/02/2022 | FC Oberlausitz | - | FSV Martinroda | 3:2 | ||||
| 15. Round | 13/02/2022 | FSV Martinroda | - | SV 09 Arnstadt | 2:2 | |
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| 19. Round | 22/02/2022 | FSV Martinroda | - | FC Carl Zeiss Jena II | 0:2 |
Germany