| 12. Round | 16/10/2021 | Rot-Weiss Essen | - | SC Wiedenbrück | 0:0 |  |
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| 13. Round | 23/10/2021 | SC Wiedenbrück | - | SV 19 Straelen | 2:0 | ||||
| 8. Round | 10/11/2021 | Sportfreunde Lotte | - | SC Wiedenbrück | 0:2 | ||||
| 17. Round | 20/11/2021 | SC Wiedenbrück | - | VfB Homberg | 3:0 | ||||
| 16. Round | 08/12/2021 | Fortuna Düsseldorf II | - | SC Wiedenbrück | 2:4 | |
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| 22. Round | 22/01/2022 | SC Wiedenbrück | - | KFC Uerdingen 05 | 5:1 | ||||
| 24. Round | 05/02/2022 | 1. FC Köln II | - | SC Wiedenbrück | 0:0 | ||||
| 20. Round | 15/02/2022 | SC Wiedenbrück | - | SV Lippstadt 08 | 2:2 | ||||
| 28. Round | 05/03/2022 | FC Wegberg-Beeck | - | SC Wiedenbrück | 1:0 | ||||
| 31. Round | 26/03/2022 | SC Wiedenbrück | - | Rot-Weiss Essen | 0:1 | ||||
| 32. Round | 02/04/2022 | SV 19 Straelen | - | SC Wiedenbrück | 1:1 | ||||
| 33. Round | 09/04/2022 | SC Wiedenbrück | - | Wuppertaler SV | 0:1 | ||||
| 35. Round | 23/04/2022 | SC Wiedenbrück | - | Fortuna Düsseldorf II | 3:1 | ||||
| 37. Round | 06/05/2022 | SC Wiedenbrück | - | Preußen Münster | 0:0 | |
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| 38. Round | 13/05/2022 | FC Schalke 04 II | - | SC Wiedenbrück | 5:1 |
Germany
Turkey