| 1. Round | 15/08/2021 | FSV Frankfurt [Youth B] | - | Stuttgarter Kickers [Youth B] | 2:1 | ||||
| 2. Round | 21/08/2021 | FC Augsburg [Youth B] | - | FSV Frankfurt [Youth B] | 0:2 | ||||
| 4. Round | 11/09/2021 | FC Ingolstadt 04 [Youth B] | - | FSV Frankfurt [Youth B] | 2:0 | ||||
| 5. Round | 19/09/2021 | FSV Frankfurt [Youth B] | - | SSV Reutlingen [Youth B] | 2:2 | ||||
| 6. Round | 25/09/2021 | SC Freiburg [Youth B] | - | FSV Frankfurt [Youth B] | 3:1 | ||||
| 8. Round | 10/10/2021 | SV Darmstadt 98 [Youth B] | - | FSV Frankfurt [Youth B] | 0:2 | ||||
| 13. Round | 05/12/2021 | FSV Frankfurt [Youth B] | - | Karlsruher SC [Youth B] | 3:2 | ||||
| 14. Round | 11/12/2021 | SV Wehen Wiesbaden [Youth B] | - | FSV Frankfurt [Youth B] | 2:1 | ||||
| 15. Round | 20/02/2022 | FSV Frankfurt [Youth B] | - | SV 07 Elversberg [Youth B] | 2:0 | ||||
| 16. Round | 27/02/2022 | VfB Stuttgart [Youth B] | - | FSV Frankfurt [Youth B] | 3:0 | ||||
| 17. Round | 06/03/2022 | FSV Frankfurt [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 1:2 | ||||
| 20. Round | 09/04/2022 | FSV Frankfurt [Youth B] | - | 1. FC Nürnberg [Youth B] | 0:3 |
Germany