| 1. Round | 14/08/2021 | 1. FSV Mainz 05 II | - | VfR Aalen | 3:1 | ||||
| 2. Round | 21/08/2021 | VfR Aalen | - | TSV Schott Mainz | 3:1 | ||||
| 3. Round | 24/08/2021 | FK Pirmasens | - | VfR Aalen | 1:0 | ||||
| 4. Round | 28/08/2021 | VfR Aalen | - | Bahlinger SC | 2:3 | ||||
| 5. Round | 04/09/2021 | TSG Balingen | - | VfR Aalen | 3:2 | ||||
| 15. Round | 26/10/2021 | VfR Aalen | - | SSV Ulm 1846 | 1:2 | ||||
| 16. Round | 30/10/2021 | Rot-Weiß Koblenz | - | VfR Aalen | 2:2 | ||||
| 17. Round | 06/11/2021 | VfR Aalen | - | 1899 Hoffenheim II | 5:2 | ||||
| 24. Round | 11/02/2022 | VfR Aalen | - | TSG Balingen | 1:2 | ||||
| 38. Round | 14/05/2022 | FC-Astoria Walldorf | - | VfR Aalen | 0:2 |  |
Germany