| 2. Round | 14/08/2021 | Bischofswerdaer FV | - | FC Carl Zeiss Jena II | 2:1 | ||||
| 4. Round | 22/08/2021 | Wacker Nordhausen | - | FC Carl Zeiss Jena II | 1:3 | ||||
| 5. Round | 28/08/2021 | FC Carl Zeiss Jena II | - | VfL Halle 96 | 3:0 | ||||
| 16. Round | 31/08/2021 | FC Carl Zeiss Jena II | - | Rot-Weiß Erfurt | 1:2 |  |
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| 3. Round | 05/09/2021 | FC Einheit Rudolstadt | - | FC Carl Zeiss Jena II | 1:3 | ||||
| 19. Round | 22/02/2022 | FSV Martinroda | - | FC Carl Zeiss Jena II | 0:2 |  |
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| 20. Round | 19/03/2022 | Blau-Weiß Zorbau | - | FC Carl Zeiss Jena II | 3:3 | ||||
| 21. Round | 02/04/2022 | FC Carl Zeiss Jena II | - | Bischofswerdaer FV | 1:1 | ||||
| 30. Round | 28/05/2022 | Inter Leipzig | - | FC Carl Zeiss Jena II | 4:0 | ||||
| 31. Round | 04/06/2022 | FC Carl Zeiss Jena II | - | Einheit Wernigerode | 0:1 | ||||
| 32. Round | 11/06/2022 | FC Carl Zeiss Jena II | - | FSV Budissa Bautzen | 4:2 | ||||
| 33. Round | 18/06/2022 | FC Carl Zeiss Jena II | - | VfB 1921 Krieschow | 2:6 |
Germany