| 2. Round | 15/08/2021 | 1. FC Rielasingen-Arlen | - | 1. FC Bruchsal | 1:0 | ||||
| 3. Round | 21/08/2021 | 1. FC Bruchsal | - | Neckarsulmer Sport-Union | 3:1 | ||||
| 4. Round | 27/08/2021 | 1. CfR Pforzheim | - | 1. FC Bruchsal | 2:1 | ||||
| 5. Round | 01/09/2021 | 1. FC Bruchsal | - | Freiburger FC | 2:2 | ||||
| 6. Round | 04/09/2021 | TSV Ilshofen | - | 1. FC Bruchsal | 2:2 | ||||
| 7. Round | 11/09/2021 | Sportfreunde Dorfmerkingen | - | 1. FC Bruchsal | 1:0 | ||||
| 8. Round | 15/09/2021 | 1. FC Bruchsal | - | FSV 08 Bietigheim-Bissingen | 0:4 | ||||
| 9. Round | 18/09/2021 | Göppinger SV | - | 1. FC Bruchsal | 4:1 | ||||
| 10. Round | 25/09/2021 | 1. FC Bruchsal | - | FV Lörrach-Brombach | 2:1 | ||||
| 12. Round | 09/10/2021 | 1. FC Bruchsal | - | SV Oberachern | 0:2 | ||||
| 14. Round | 22/10/2021 | 1. FC Bruchsal | - | FC-Astoria Walldorf II | 1:0 | ||||
| 17. Round | 13/11/2021 | TSG Backnang | - | 1. FC Bruchsal | 2:3 | ||||
| 18. Round | 20/11/2021 | 1. FC Bruchsal | - | FV Ravensburg | 2:2 |
Germany