| 3. Round | 24/08/2021 | Bonner SC | - | SV 19 Straelen | 1:3 | ||||
| 4. Round | 28/08/2021 | SV 19 Straelen | - | Wuppertaler SV | 1:4 | ||||
| 5. Round | 04/09/2021 | Fortuna Köln | - | SV 19 Straelen | 1:0 | ||||
| 9. Round | 25/09/2021 | FC Schalke 04 II | - | SV 19 Straelen | 1:1 | ||||
| 7. Round | 06/10/2021 | VfB Homberg | - | SV 19 Straelen | 0:1 | ||||
| 11. Round | 09/10/2021 | Rot-Weiß Oberhausen | - | SV 19 Straelen | 0:0 | ||||
| 12. Round | 16/10/2021 | SV 19 Straelen | - | KFC Uerdingen 05 | 2:0 | ||||
| 13. Round | 23/10/2021 | SC Wiedenbrück | - | SV 19 Straelen | 2:0 | ||||
| 14. Round | 30/10/2021 | SV 19 Straelen | - | 1. FC Köln II | 1:2 | ||||
| 18. Round | 27/11/2021 | SV 19 Straelen | - | FC Wegberg-Beeck | 0:0 | ||||
| 19. Round | 04/12/2021 | SV Rödinghausen | - | SV 19 Straelen | 3:0 | ||||
| 24. Round | 05/02/2022 | SV 19 Straelen | - | Fortuna Köln | 0:2 | ||||
| 25. Round | 12/02/2022 | Fortuna Düsseldorf II | - | SV 19 Straelen | 0:4 |  |
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| 26. Round | 19/02/2022 | SV 19 Straelen | - | VfB Homberg | 0:4 | ||||
| 27. Round | 26/02/2022 | Preußen Münster | - | SV 19 Straelen | 4:0 | ||||
| 28. Round | 05/03/2022 | SV 19 Straelen | - | FC Schalke 04 II | 2:1 | ||||
| 29. Round | 12/03/2022 | SV Lippstadt 08 | - | SV 19 Straelen | 1:2 |
Germany
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