| 12. Round | 02/02/2022 | Olympiakos Piraeus II | - | Xanthi FC | 1:1 | ||||
| 17. Round | 05/02/2022 | Olympiakos Volou | - | Olympiakos Piraeus II | 2:3 |  |
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| 18. Round | 13/02/2022 | PAOK Saloniki II | - | Olympiakos Piraeus II | 1:0 | ||||
| 19. Round | 16/02/2022 | Olympiakos Piraeus II | - | AO Trikala | 2:0 | ||||
| 21. Round | 26/02/2022 | Olympiakos Piraeus II | - | Apollon Lárissa | 0:1 | ||||
| 24. Round | 12/03/2022 | Olympiakos Piraeus II | - | AEP Iraklis FC | 0:0 | ||||
| 28. Round | 02/04/2022 | Olympiakos Piraeus II | - | Pierikos Katerini | 3:0 | |
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| 31. Round | 13/04/2022 | AO Kavala | - | Olympiakos Piraeus II | 0:0 | ||||
| 32. Round | 16/04/2022 | Olympiakos Piraeus II | - | Almopos Arideas | 2:1 | ||||
| 26. Round | 20/04/2022 | Olympiakos Piraeus II | - | Apollon Pontou | 2:0 | ||||
| 33. Round | 27/04/2022 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 | ||||
| 34. Round | 01/05/2022 | Olympiakos Piraeus II | - | Olympiakos Volou | 3:2 |
Poland