| 6. Round | 06/08/2021 | Viktoria Aschaffenburg | - | Wacker Burghausen | 3:1 | ||||
| 7. Round | 13/08/2021 | Wacker Burghausen | - | TSV Buchbach | 1:1 |  |
 |
||
| 8. Round | 17/08/2021 | TSV 1896 Rain | - | Wacker Burghausen | 0:4 | |
|||
| 9. Round | 21/08/2021 | Wacker Burghausen | - | SpVgg Greuther Fürth II | 1:4 | ||||
| 10. Round | 27/08/2021 | TSV Aubstadt | - | Wacker Burghausen | 1:2 | ||||
| 11. Round | 31/08/2021 | FV Illertissen | - | Wacker Burghausen | 1:2 | ||||
| 12. Round | 04/09/2021 | Wacker Burghausen | - | 1. FC Nürnberg II | 3:2 | |
|||
| 13. Round | 14/09/2021 | FC Augsburg II | - | Wacker Burghausen | 3:1 | ||||
| 14. Round | 17/09/2021 | Wacker Burghausen | - | SV Heimstetten | 0:3 | ||||
| 15. Round | 24/09/2021 | SC Eltersdorf | - | Wacker Burghausen | 1:5 | ||||
| 16. Round | 02/10/2021 | Wacker Burghausen | - | VfB Eichstätt | 3:0 | ||||
| 17. Round | 08/10/2021 | FC Memmingen | - | Wacker Burghausen | 0:3 | ||||
| 18. Round | 15/10/2021 | Wacker Burghausen | - | Bayern München II | 2:2 | |
|||
| 19. Round | 23/10/2021 | FC Pipinsried | - | Wacker Burghausen | 1:0 | ||||
| 20. Round | 30/10/2021 | SV Schalding-Heining | - | Wacker Burghausen | 1:0 | ||||
| 23. Round | 19/11/2021 | Wacker Burghausen | - | SpVgg Bayreuth | 0:1 | |
Germany