| 3. Round | 27/07/2021 | TSV Aubstadt | - | SpVgg Bayreuth | 1:2 | ||||
| 5. Round | 03/08/2021 | 1. FC Nürnberg II | - | SpVgg Bayreuth | 0:3 | ||||
| 7. Round | 13/08/2021 | SV Heimstetten | - | SpVgg Bayreuth | 2:3 | ||||
| 8. Round | 17/08/2021 | SpVgg Bayreuth | - | SC Eltersdorf | 3:1 | ||||
| 9. Round | 21/08/2021 | VfB Eichstätt | - | SpVgg Bayreuth | 1:3 | ||||
| 12. Round | 04/09/2021 | SpVgg Bayreuth | - | FC Pipinsried | 1:2 | ||||
| 13. Round | 11/09/2021 | SV Schalding-Heining | - | SpVgg Bayreuth | 0:1 | ||||
| 17. Round | 09/10/2021 | SpVgg Bayreuth | - | 1. FC Schweinfurt 05 | 0:3 | ||||
| 20. Round | 30/10/2021 | SpVgg Bayreuth | - | TSV 1896 Rain | 1:0 | ||||
| 27. Round | 04/03/2022 | SC Eltersdorf | - | SpVgg Bayreuth | 0:3 | ||||
| 31. Round | 03/05/2022 | FC Pipinsried | - | SpVgg Bayreuth | 1:2 | ||||
| 36. Round | 07/05/2022 | 1. FC Schweinfurt 05 | - | SpVgg Bayreuth | 1:5 | ||||
| 38. Round | 21/05/2022 | TSV Buchbach | - | SpVgg Bayreuth | 5:2 |
Germany