| 2. Round | 08/04/2022 | SSVg Velbert | - | 1. FC Kleve | 4:3 | ||||
| 3. Round | 18/04/2022 | 1. FC Kleve | - | TVD Velbert | 1:2 | ||||
| 4. Round | 24/04/2022 | 1. FC Kleve | - | 1. FC Bocholt | 1:1 |  |
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| 5. Round | 29/04/2022 | 1. FC Kleve | - | Sportfreunde Baumberg | 3:1 | ||||
| 6. Round | 08/05/2022 | 1. FC Monheim | - | 1. FC Kleve | 3:2 | |
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| 1. Round | 11/05/2022 | TSV Meerbusch | - | 1. FC Kleve | 3:1 |  |
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| 8. Round | 22/05/2022 | 1. FC Kleve | - | VfB 03 Hilden | 0:2 | ||||
| 9. Round | 29/05/2022 | 1. FC Kleve | - | Germania Ratingen 04/19 | 0:5 | ||||
| 10. Round | 03/06/2022 | 1. FC Kleve | - | SpVg Schonnebeck | 3:0 | |
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| 11. Round | 10/06/2022 | 1. FC Kleve | - | Schwarz-Weiß Essen | 3:2 |
Germany