| 1. Round | 07/08/2021 | Freiburger FC | - | Neckarsulmer Sport-Union | 2:3 | ||||
| 2. Round | 14/08/2021 | Neckarsulmer Sport-Union | - | TSV Ilshofen | 4:1 |  |
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| 3. Round | 21/08/2021 | 1. FC Bruchsal | - | Neckarsulmer Sport-Union | 3:1 | |
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| 4. Round | 27/08/2021 | Neckarsulmer Sport-Union | - | FSV 08 Bietigheim-Bissingen | 3:2 | ||||
| 5. Round | 01/09/2021 | Göppinger SV | - | Neckarsulmer Sport-Union | 1:1 | ||||
| 6. Round | 04/09/2021 | Neckarsulmer Sport-Union | - | FV Lörrach-Brombach | 2:0 | ||||
| 7. Round | 10/09/2021 | FC Nöttingen | - | Neckarsulmer Sport-Union | 2:1 |  |
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| 8. Round | 15/09/2021 | Neckarsulmer Sport-Union | - | SV Oberachern | 1:0 | ||||
| 10. Round | 25/09/2021 | Neckarsulmer Sport-Union | - | FC-Astoria Walldorf II | 1:3 | ||||
| 11. Round | 02/10/2021 | SGV Freiberg | - | Neckarsulmer Sport-Union | 1:1 | ||||
| 12. Round | 09/10/2021 | Neckarsulmer Sport-Union | - | SSV Reutlingen | 2:2 | ||||
| 13. Round | 16/10/2021 | TSG Backnang | - | Neckarsulmer Sport-Union | 3:0 | ||||
| 14. Round | 23/10/2021 | Neckarsulmer Sport-Union | - | FV Ravensburg | 2:2 |
Germany