| 10. Round | 17/10/2021 | 1. FC Merseburg | - | FC Grimma | annull. | ||||
| 11. Round | 23/10/2021 | FC Grimma | - | FC An der Fahner Höhe | 0:0 | ||||
| 12. Round | 30/10/2021 | FC Oberlausitz | - | FC Grimma | 1:0 | ||||
| 13. Round | 06/11/2021 | FC Grimma | - | SV 09 Arnstadt | 3:2 | ||||
| 15. Round | 13/02/2022 | FC Grimma | - | Inter Leipzig | 5:1 | ||||
| 22. Round | 13/03/2022 | Union Sandersdorf | - | FC Grimma | 1:0 |  |
|||
| 23. Round | 10/04/2022 | FC Grimma | - | FSV Martinroda | 3:1 | ||||
| 24. Round | 16/04/2022 | Blau-Weiß Zorbau | - | FC Grimma | 1:1 | ||||
| 16. Round | 20/04/2022 | Einheit Wernigerode | - | FC Grimma | 1:0 | ||||
| 25. Round | 23/04/2022 | FC Grimma | - | Bischofswerdaer FV | 1:1 | ||||
| 26. Round | 30/04/2022 | FC Einheit Rudolstadt | - | FC Grimma | 1:1 | ||||
| 27. Round | 08/05/2022 | FC Grimma | - | Wacker Nordhausen | 1:0 | ||||
| 28. Round | 15/05/2022 | VfL Halle 96 | - | FC Grimma | 0:0 | ||||
| 17. Round | 21/05/2022 | FC Grimma | - | FC Carl Zeiss Jena II | 3:0 | ||||
| 30. Round | 29/05/2022 | FC An der Fahner Höhe | - | FC Grimma | 0:2 | ||||
| 31. Round | 04/06/2022 | FC Grimma | - | FC Oberlausitz | 3:1 |
Germany