| 2. Round | 18/04/2022 | Westfalia Rhynern | - | FC Gütersloh | 1:0 | ||||
| 3. Round | 24/04/2022 | FC Gütersloh | - | TuS Erndtebrück | 5:3 | ||||
| 4. Round | 01/05/2022 | SG Wattenscheid 09 | - | FC Gütersloh | 0:1 | ||||
| 1. Round | 05/05/2022 | FC Gütersloh | - | Sportfreunde Siegen | 1:1 | ||||
| 5. Round | 08/05/2022 | FC Gütersloh | - | FCE Rheine | 2:0 | ||||
| 6. Round | 15/05/2022 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 22/05/2022 | FC Gütersloh | - | SV Schermbeck | 1:1 | ||||
| 8. Round | 29/05/2022 | FC Gütersloh | - | ASC 09 Dortmund | 1:2 | ||||
| 9. Round | 06/06/2022 | 1. FC Kaan-Marienborn | - | FC Gütersloh | 4:2 |
Germany