| 1. Round | 03/04/2022 | SpVg Schonnebeck | - | 1. FC Monheim | 0:0 | ||||
| 2. Round | 08/04/2022 | 1. FC Monheim | - | Schwarz-Weiß Essen | 2:2 | ||||
| 3. Round | 18/04/2022 | TSV Meerbusch | - | 1. FC Monheim | 0:2 | ||||
| 4. Round | 22/04/2022 | SSVg Velbert | - | 1. FC Monheim | 5:1 |  |
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| 5. Round | 29/04/2022 | 1. FC Monheim | - | TVD Velbert | 1:1 | ||||
| 6. Round | 08/05/2022 | 1. FC Monheim | - | 1. FC Kleve | 3:2 | ||||
| 7. Round | 14/05/2022 | Sportfreunde Baumberg | - | 1. FC Monheim | 3:2 | ||||
| 8. Round | 22/05/2022 | 1. FC Monheim | - | 1. FC Bocholt | 0:0 | ||||
| 10. Round | 03/06/2022 | VfB 03 Hilden | - | 1. FC Monheim | 2:0 |
Germany