| 1. Round | 14/08/2021 | Rot-Weiß Koblenz | - | VfB Stuttgart II | 0:3 |  |
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| 2. Round | 21/08/2021 | VfB Stuttgart II | - | 1899 Hoffenheim II | 1:3 | ||||
| 4. Round | 29/08/2021 | VfB Stuttgart II | - | FC-Astoria Walldorf | 2:3 | ||||
| 5. Round | 03/09/2021 | 1. FSV Mainz 05 II | - | VfB Stuttgart II | 2:4 |  |
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| 12. Round | 09/10/2021 | VfB Stuttgart II | - | TSV Steinbach Haiger | 0:0 | |
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| 18. Round | 14/11/2021 | Kickers Offenbach | - | VfB Stuttgart II | 3:1 | |
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| 19. Round | 20/11/2021 | VfB Stuttgart II | - | SSV Ulm 1846 | 0:1 | ||||
| 20. Round | 27/11/2021 | VfB Stuttgart II | - | Rot-Weiß Koblenz | 2:0 | ||||
| 21. Round | 03/12/2021 | 1899 Hoffenheim II | - | VfB Stuttgart II | 2:0 | ||||
| 22. Round | 11/12/2021 | VfB Stuttgart II | - | Hessen Kassel | 1:3 | ||||
| 23. Round | 17/12/2021 | FC-Astoria Walldorf | - | VfB Stuttgart II | 1:1 | ||||
| 24. Round | 12/02/2022 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 0:2 | |
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| 26. Round | 26/02/2022 | VfB Stuttgart II | - | FK Pirmasens | 2:1 | |
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| 27. Round | 05/03/2022 | Bahlinger SC | - | VfB Stuttgart II | 0:0 | ||||
| 28. Round | 11/03/2022 | VfB Stuttgart II | - | TSG Balingen | 1:2 | ||||
| 38. Round | 14/05/2022 | SSV Ulm 1846 | - | VfB Stuttgart II | 3:2 |
Germany