1. Round | 14/08/2021 | Fortuna Düsseldorf II | - | Sportfreunde Lotte | 2:1 | ||||
9. Round | 25/09/2021 | 1. FC Köln II | - | Sportfreunde Lotte | 4:0 | ||||
10. Round | 01/10/2021 | Sportfreunde Lotte | - | Alemannia Aachen | 1:0 | ||||
13. Round | 23/10/2021 | Sportfreunde Lotte | - | FC Wegberg-Beeck | 1:2 | ||||
15. Round | 06/11/2021 | Sportfreunde Lotte | - | Rot Weiss Ahlen | 4:1 | ||||
8. Round | 10/11/2021 | Sportfreunde Lotte | - | SC Wiedenbrück | 0:2 | ||||
16. Round | 13/11/2021 | Rot-Weiss Essen | - | Sportfreunde Lotte | 3:1 | ||||
17. Round | 21/11/2021 | Sportfreunde Lotte | - | SV 19 Straelen | 1:2 | ||||
33. Round | 09/04/2022 | Sportfreunde Lotte | - | SV Rödinghausen | 0:1 | ||||
37. Round | 08/05/2022 | Sportfreunde Lotte | - | Wuppertaler SV | 2:1 |