| 1. Round | 30/07/2005 | Kickers Emden | - | Rot-Weiss Essen | 0:3 | ||||
| 2. Round | 02/08/2005 | Rot-Weiss Essen | - | VfB Lübeck | 1:2 | ||||
| 8. Round | 10/09/2005 | Rot-Weiss Essen | - | Preußen Münster | 2:0 | ||||
| 18. Round | 20/11/2005 | Werder Bremen II | - | Rot-Weiss Essen | 0:3 | ||||
| 19. Round | 25/11/2005 | Rot-Weiss Essen | - | Rot-Weiß Erfurt | 5:0 |  |
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| 20. Round | 03/12/2005 | Rot-Weiss Essen | - | Kickers Emden | 3:1 | ||||
| 23. Round | 10/02/2006 | Rot-Weiß Oberhausen | - | Rot-Weiss Essen | 0:0 | ||||
| 24. Round | 18/02/2006 | Rot-Weiss Essen | - | Wuppertaler SV | 3:2 | |
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| 26. Round | 04/03/2006 | Rot-Weiss Essen | - | Hertha BSC II | 2:0 | ||||
| 27. Round | 10/03/2006 | Preußen Münster | - | Rot-Weiss Essen | 1:3 | ||||
| 30. Round | 01/04/2006 | Rot-Weiss Essen | - | Holstein Kiel | 2:1 | ||||
| 31. Round | 08/04/2006 | VfL Osnabrück | - | Rot-Weiss Essen | 1:4 | ||||
| 34. Round | 29/04/2006 | 1. FC Köln II | - | Rot-Weiss Essen | 1:1 | ||||
| 35. Round | 06/05/2006 | Rot-Weiss Essen | - | FC St. Pauli | 2:0 |
Germany