| 1. Round | 14/08/2021 | FK Pirmasens | - | Bahlinger SC | 0:0 | ||||
| 2. Round | 21/08/2021 | TSG Balingen | - | FK Pirmasens | 1:2 | ||||
| 4. Round | 28/08/2021 | FC Gießen | - | FK Pirmasens | 0:1 | ||||
| 5. Round | 04/09/2021 | FK Pirmasens | - | TSV Steinbach Haiger | 1:2 | ||||
| 6. Round | 12/09/2021 | SG Sonnenhof Großaspach | - | FK Pirmasens | 3:1 | ||||
| 7. Round | 15/09/2021 | FK Pirmasens | - | VfB Stuttgart II | 2:3 |  |
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| 8. Round | 18/09/2021 | FSV Frankfurt | - | FK Pirmasens | 2:2 | ||||
| 9. Round | 24/09/2021 | FK Pirmasens | - | FC 08 Homburg | 0:1 | ||||
| 11. Round | 02/10/2021 | FK Pirmasens | - | Kickers Offenbach | 0:2 | ||||
| 24. Round | 12/02/2022 | TSV Steinbach Haiger | - | FK Pirmasens | 2:0 | ||||
| 25. Round | 19/02/2022 | FK Pirmasens | - | SG Sonnenhof Großaspach | 0:4 | ||||
| 29. Round | 19/03/2022 | FK Pirmasens | - | SV 07 Elversberg | 0:3 | ||||
| 30. Round | 26/03/2022 | Kickers Offenbach | - | FK Pirmasens | 3:0 | ||||
| 34. Round | 16/04/2022 | Hessen Kassel | - | FK Pirmasens | 0:3 | ||||
| 35. Round | 23/04/2022 | FK Pirmasens | - | FC-Astoria Walldorf | 1:2 | ||||
| 36. Round | 01/05/2022 | 1. FSV Mainz 05 II | - | FK Pirmasens | 4:1 |
Germany