| 6. Round | 26/09/2020 | FC Schalke 04 II | - | SV 19 Straelen | 1:2 | ||||
| 7. Round | 03/10/2020 | VfB Homberg | - | FC Schalke 04 II | 1:2 | ||||
| 9. Round | 18/10/2020 | Alemannia Aachen | - | FC Schalke 04 II | 0:0 | ||||
| 11. Round | 24/10/2020 | Sportfreunde Lotte | - | FC Schalke 04 II | 0:0 | ||||
| 18. Round | 28/11/2020 | FC Schalke 04 II | - | SV Lippstadt 08 | 6:2 | ||||
| 20. Round | 12/12/2020 | FC Schalke 04 II | - | Fortuna Köln | 1:1 | ||||
| 21. Round | 19/12/2020 | Preußen Münster | - | FC Schalke 04 II | 1:1 |
Germany