| 4. Round | 28/08/2022 | 1. FSV Mainz 05 II | - | Bahlinger SC | 0:2 dec. | ||||
| 5. Round | 04/09/2022 | Eintracht Trier | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 10. Round | 02/10/2022 | 1. FSV Mainz 05 II | - | SGV Freiberg | 1:2 |  |
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| 9. Round | 05/10/2022 | FSV Frankfurt | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 14. Round | 30/10/2022 | 1. FSV Mainz 05 II | - | Hessen Kassel | 3:1 | ||||
| 17. Round | 20/11/2022 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 4:1 | |
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| 18. Round | 26/11/2022 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 4:1 | ||||
| 19. Round | 03/12/2022 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 1:1 | ||||
| 20. Round | 10/12/2022 | 1. FSV Mainz 05 II | - | SG Barockstadt Fulda-Lehnerz | 1:1 | ||||
| 25. Round | 01/04/2023 | Rot-Weiß Koblenz | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 26. Round | 04/04/2023 | 1. FSV Mainz 05 II | - | FSV Frankfurt | 1:1 | ||||
| 27. Round | 08/04/2023 | SGV Freiberg | - | 1. FSV Mainz 05 II | 4:0 | ||||
| 30. Round | 30/04/2023 | 1. FSV Mainz 05 II | - | FC 08 Homburg | 2:2 | ||||
| 31. Round | 06/05/2023 | Hessen Kassel | - | 1. FSV Mainz 05 II | 1:0 | |
Germany