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| 1st(1st leg) | FK Minsk | - | FC Viitorul Constanța | 2:2 (2:1) | ||
| 2nd (2nd leg) | FC Viitorul Constanța | - | FK Minsk | 5:1 (0:1) | ||
| 1st(1st leg): 29/09/2015 16:00 | 2nd (2nd leg): 21/10/2015 16:00 | Winner: FC Viitorul Constanța | ||||
| 1st(1st leg) | FK Senica | - | Torino FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Torino FC | - | FK Senica | 2:1 (1:1) | ||
| 1st(1st leg): 29/09/2015 17:00 | 2nd (2nd leg): 21/10/2015 17:30 | Winner: Torino FC | ||||
| 1st(1st leg) | Villarreal CF | - | Servette FC | 2:3 (0:1) | ||
| 2nd (2nd leg) | Servette FC | - | Villarreal CF | 1:2 (0:0) | ||
| 1st(1st leg): 30/09/2015 12:00 | 2nd (2nd leg): 21/10/2015 13:00 | Winner: Servette FC | ||||
| 1st(1st leg) | Spartak Moskva | - | Rävan Baku | 4:0 (0:0) | ||
| 2nd (2nd leg) | Rävan Baku | - | Spartak Moskva | 0:0 (0:0) | ||
| 1st(1st leg): 30/09/2015 13:00 | 2nd (2nd leg): 21/10/2015 15:00 | Winner: Spartak Moskva | ||||
| 1st(1st leg) | FK Rad Beograd | - | NK Domžale | 0:1 (0:1) | ||
| 2nd (2nd leg) | NK Domžale | - | FK Rad Beograd | 2:3 (0:0, 0:1) pso | ||
| 1st(1st leg): 30/09/2015 13:00 | 2nd (2nd leg): 20/10/2015 15:00 | Winner: FK Rad Beograd | ||||
| 1st(1st leg) | FK Aktobe | - | Beşiktaş | 0:2 (0:1) | ||
| 2nd (2nd leg) | Beşiktaş | - | FK Aktobe | 4:0 (1:0) | ||
| 1st(1st leg): 30/09/2015 14:00 | 2nd (2nd leg): 21/10/2015 12:00 | Winner: Beşiktaş | ||||
| 1st(1st leg) | APOEL Nikosia | - | Puskás FC | 3:3 (1:2) | ||
| 2nd (2nd leg) | Puskás FC | - | APOEL Nikosia | 6:1 (2:1) | ||
| 1st(1st leg): 30/09/2015 14:00 | 2nd (2nd leg): 21/10/2015 17:00 | Winner: Puskás FC | ||||
| 1st(1st leg) | FC Schalke 04 | - | AFC Ajax | 2:3 (1:2) | ||
| 2nd (2nd leg) | AFC Ajax | - | FC Schalke 04 | 2:0 (1:0) | ||
| 1st(1st leg): 30/09/2015 15:00 | 2nd (2nd leg): 21/10/2015 18:00 | Winner: AFC Ajax | ||||
| 1st(1st leg) | 1. FK Příbram | - | FC Zimbru | 2:0 (1:0) | ||
| 2nd (2nd leg) | FC Zimbru | - | 1. FK Příbram | 1:2 (0:1) | ||
| 1st(1st leg): 30/09/2015 16:00 | 2nd (2nd leg): 21/10/2015 15:00 | Winner: 1. FK Příbram | ||||
| 1st(1st leg) | HJK Helsinki | - | Celtic FC | 0:5 (0:3) | ||
| 2nd (2nd leg) | Celtic FC | - | HJK Helsinki | 1:1 (0:0) | ||
| 1st(1st leg): 30/09/2015 16:30 | 2nd (2nd leg): 20/10/2015 19:00 | Winner: Celtic FC | ||||
| 1st(1st leg) | RB Salzburg | - | Željezničar Sarajevo | 4:0 (2:0) | ||
| 2nd (2nd leg) | Željezničar Sarajevo | - | RB Salzburg | 2:1 (2:0) | ||
| 1st(1st leg): 30/09/2015 17:00 | 2nd (2nd leg): 14/10/2015 19:00 | Winner: RB Salzburg | ||||
| 1st(1st leg) | PFC Litex Lovech | - | Legia Warszawa | 1:2 (0:1) | ||
| 2nd (2nd leg) | Legia Warszawa | - | PFC Litex Lovech | 3:1 (1:0) | ||
| 1st(1st leg): 30/09/2015 17:00 | 2nd (2nd leg): 20/10/2015 17:00 | Winner: Legia Warszawa | ||||
| 1st(1st leg) | IF Elfsborg | - | UMF Stjarnan | 2:0 (1:0) | ||
| 2nd (2nd leg) | UMF Stjarnan | - | IF Elfsborg | 1:0 (1:0) | ||
| 1st(1st leg): 30/09/2015 17:00 | 2nd (2nd leg): 21/10/2015 19:00 | Winner: IF Elfsborg | ||||
| 1st(1st leg) | FC Midtjylland | - | FC Saburtalo | 3:1 (2:0) | ||
| 2nd (2nd leg) | FC Saburtalo | - | FC Midtjylland | 1:2 (0:1) | ||
| 1st(1st leg): 30/09/2015 17:00 | 2nd (2nd leg): 21/10/2015 16:00 | Winner: FC Midtjylland | ||||
| 1st(1st leg) | Stade Reims | - | Middlesbrough FC | 5:3 (2:0) | ||
| 2nd (2nd leg) | Middlesbrough FC | - | Stade Reims | 3:0 (0:0) | ||
| 1st(1st leg): 30/09/2015 18:00 | 2nd (2nd leg): 21/10/2015 19:00 | Winner: Middlesbrough FC | ||||
| 1st(1st leg) | SK Brann | - | RSC Anderlecht | 1:1 (0:0) | ||
| 2nd (2nd leg) | RSC Anderlecht | - | SK Brann | 5:0 (2:0) | ||
| 1st(1st leg): 30/09/2015 18:00 | 2nd (2nd leg): 07/10/2015 18:30 | Winner: RSC Anderlecht | ||||
