1st(1st leg) Shakhter Soligorsk - FC Nitra 2:0 (0:0)
2nd (2nd leg) FC Nitra - Shakhter Soligorsk 3:0 (1:0)
1st(1st leg): 29/10/2017 13:00 2nd (2nd leg): 21/11/2017 16:00 Winner: FC Nitra
1st(1st leg) Lokomotiva Zagreb - Željezničar Sarajevo 1:1 (0:1)
2nd (2nd leg) Željezničar Sarajevo - Lokomotiva Zagreb 0:0 (0:0)
1st(1st leg): 31/10/2017 13:00 2nd (2nd leg): 22/11/2017 15:00 Winner: Željezničar Sarajevo
1st(1st leg) Legia Warszawa - AFC Ajax 1:4 (1:1)
2nd (2nd leg) AFC Ajax - Legia Warszawa 0:2 (0:1)
1st(1st leg): 31/10/2017 17:00 2nd (2nd leg): 21/11/2017 15:00 Winner: AFC Ajax
1st(1st leg) Inter - Esbjerg fB 4:1 (2:1)
2nd (2nd leg) Esbjerg fB - Inter 0:6 (0:2)
1st(1st leg): 01/11/2017 13:30 2nd (2nd leg): 22/11/2017 15:00 Winner: Inter
1st(1st leg) FK Krasnodar - Budapest Honvéd 8:0 (3:0)
2nd (2nd leg) Budapest Honvéd - FK Krasnodar 1:1 (0:0)
1st(1st leg): 01/11/2017 14:00 2nd (2nd leg): 22/11/2017 15:00 Winner: FK Krasnodar
1st(1st leg) FC Zimbru - Molde FK 0:0 (0:0)
2nd (2nd leg) Molde FK - FC Zimbru 2:0 (0:0)
1st(1st leg): 01/11/2017 16:00 2nd (2nd leg): 22/11/2017 17:00 Winner: Molde FK
1st(1st leg) FK Brodarac - FC Saburtalo 1:1 (1:0)
2nd (2nd leg) FC Saburtalo - FK Brodarac 2:2 (0:1)
1st(1st leg): 01/11/2017 16:00 2nd (2nd leg): 22/11/2017 14:00 Winner: FK Brodarac
1st(1st leg) Sparta Praha - RB Salzburg 2:4 (1:2)
2nd (2nd leg) RB Salzburg - Sparta Praha 2:0 (1:0)
1st(1st leg): 01/11/2017 16:00 2nd (2nd leg): 21/11/2017 17:00 Winner: RB Salzburg