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| 1st(1st leg) | Hajduk Split | - | Gabala FK | 3:0 (1:0) | ||
| 2nd (2nd leg) | Gabala FK | - | Hajduk Split | 1:2 (0:0) | ||
| 1st(1st leg): 12/09/2022 16:00 | 2nd (2nd leg): 04/10/2022 14:00 | Winner: Hajduk Split | ||||
| 1st(1st leg) | KRC Genk | - | Slavia Praha | 1:2 (0:1) | ||
| 2nd (2nd leg) | Slavia Praha | - | KRC Genk | 2:4 (2:1) | ||
| 1st(1st leg): 14/09/2022 15:00 | 2nd (2nd leg): 05/10/2022 13:00 | Winner: KRC Genk | ||||
| 1st(1st leg) | MTK Budapest | - | FK Jelgava | 3:0 (1:0) | ||
| 2nd (2nd leg) | FK Jelgava | - | MTK Budapest | 0:1 (0:0) | ||
| 1st(1st leg): 14/09/2022 15:00 | 2nd (2nd leg): 05/10/2022 12:00 | Winner: MTK Budapest | ||||
| 1st(1st leg) | FK Csikszereda | - | Galatasaray | 1:1 (0:1) | ||
| 2nd (2nd leg) | Galatasaray | - | FK Csikszereda | 4:0 (0:0) | ||
| 1st(1st leg): 14/09/2022 15:00 | 2nd (2nd leg): 05/10/2022 13:00 | Winner: Galatasaray | ||||
| 1st(1st leg) | Rukh Lviv | - | Zagłębie Lubin | 1:0 (1:0) | ||
| 2nd (2nd leg) | Zagłębie Lubin | - | Rukh Lviv | 0:0 (0:0) | ||
| 1st(1st leg): 14/09/2022 16:00 | 2nd (2nd leg): 05/10/2022 17:00 | Winner: Rukh Lviv | ||||
| 1st(1st leg) | Panathinaikos | - | Slavia Sofia | 8:0 (4:0) | ||
| 2nd (2nd leg) | Slavia Sofia | - | Panathinaikos | 2:2 (1:0) | ||
| 1st(1st leg): 14/09/2022 16:00 | 2nd (2nd leg): 05/10/2022 15:00 | Winner: Panathinaikos | ||||
| 1st(1st leg) | BSC Young Boys | - | NK Domžale | 3:0 (1:0) | ||
| 2nd (2nd leg) | NK Domžale | - | BSC Young Boys | 2:2 (1:0) | ||
| 1st(1st leg): 14/09/2022 17:00 | 2nd (2nd leg): 05/10/2022 17:00 | Winner: BSC Young Boys | ||||
| 1st(1st leg) | AZ Alkmaar | - | Shamrock Rovers | 5:0 (1:0) | ||
| 2nd (2nd leg) | Shamrock Rovers | - | AZ Alkmaar | 1:1 (0:1) | ||
| 1st(1st leg): 14/09/2022 17:00 | 2nd (2nd leg): 04/10/2022 19:45 | Winner: AZ Alkmaar | ||||
| 1st(1st leg) | FK Žalgiris | - | FK AS Trenčín | 2:1 (1:1) | ||
| 2nd (2nd leg) | FK AS Trenčín | - | FK Žalgiris | 4:0 (2:0) | ||
| 1st(1st leg): 14/09/2022 17:00 | 2nd (2nd leg): 05/10/2022 17:00 | Winner: FK AS Trenčín | ||||
| 1st(1st leg) | FC Ashdod | - | Borac Banja Luka | 2:0 (1:0) | ||
| 2nd (2nd leg) | Borac Banja Luka | - | FC Ashdod | 0:3 (0:1) | ||
| 1st(1st leg): 14/09/2022 17:00 | 2nd (2nd leg): 12/10/2022 18:00 | Winner: FC Ashdod | ||||
| 1st(1st leg) | Crvena Zvezda | - | Omonia Nikosia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Omonia Nikosia | - | Crvena Zvezda | 1:2 (0:2) | ||
| 1st(1st leg): 14/09/2022 18:00 | 2nd (2nd leg): 05/10/2022 15:00 | Winner: Crvena Zvezda | ||||
| 1st(1st leg) | FC Nantes | - | Pyunik FC | 2:0 (0:0) | ||
| 2nd (2nd leg) | Pyunik FC | - | FC Nantes | 0:3 (0:1) | ||
| 1st(1st leg): 14/09/2022 18:00 | 2nd (2nd leg): 05/10/2022 13:00 | Winner: FC Nantes | ||||
| 1st(1st leg) | AIK Solna | - | RFCU Luxemburg | 5:0 (1:0) | ||
| 2nd (2nd leg) | RFCU Luxemburg | - | AIK Solna | 2:3 (0:0) | ||
| 1st(1st leg): 14/09/2022 18:00 | 2nd (2nd leg): 05/10/2022 18:00 | Winner: AIK Solna | ||||
| 1st(1st leg) | Molde FK | - | Hibernian FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Hibernian FC | - | Molde FK | 5:4 (1:0, 2:1) pso | ||
| 1st(1st leg): 14/09/2022 18:00 | 2nd (2nd leg): 05/10/2022 19:00 | Winner: Hibernian FC | ||||
| 1st(1st leg) | FK Astana | - | KF Apolonia Fier | 1:1 (1:1) | ||
| 2nd (2nd leg) | KF Apolonia Fier | - | FK Astana | 3:1 (1:0) | ||
| 1st(1st leg): 15/09/2022 14:00 | 2nd (2nd leg): 05/10/2022 13:00 | Winner: KF Apolonia Fier | ||||
| 1st(1st leg) | Coleraine FC | - | FK Pobeda Junior | 3:2 (1:2) | ||
| 2nd (2nd leg) | FK Pobeda Junior | - | Coleraine FC | 2:2 (1:0) | ||
| 1st(1st leg): 28/09/2022 19:30 | 2nd (2nd leg): 05/10/2022 13:00 | Winner: Coleraine FC | ||||
