1st(1st leg) Anorthosis Famagusta - Rangers FC 1:2 (0:0)
2nd (2nd leg) Rangers FC - Anorthosis Famagusta 2:0 (1:0)
1st(1st leg): 09/08/2005 19:00 2nd (2nd leg): 24/08/2005 19:45 Winner: Rangers FC
1st(1st leg) Wisła Kraków - Panathinaikos 3:1 (1:1)
2nd (2nd leg) Panathinaikos - Wisła Kraków 4:1 (0:0, 3:1) aet
1st(1st leg): 09/08/2005 19:45 2nd (2nd leg): 23/08/2005 19:45 Winner: Panathinaikos
1st(1st leg) Vålerenga IF - Club Brugge KV 1:0 (0:0)
2nd (2nd leg) Club Brugge KV - Vålerenga IF 4:3 (0:0, 1:0, 1:0) pso
1st(1st leg): 09/08/2005 20:00 2nd (2nd leg): 24/08/2005 19:30 Winner: Club Brugge KV
1st(1st leg) Everton FC - Villarreal CF 1:2 (1:2)
2nd (2nd leg) Villarreal CF - Everton FC 2:1 (1:0)
1st(1st leg): 09/08/2005 20:05 2nd (2nd leg): 24/08/2005 21:00 Winner: Villarreal CF
1st(1st leg) Manchester United - Debreceni VSC 3:0 (1:0)
2nd (2nd leg) Debreceni VSC - Manchester United 0:3 (0:1)
1st(1st leg): 09/08/2005 20:05 2nd (2nd leg): 24/08/2005 19:30 Winner: Manchester United
1st(1st leg) Real Betis - AS Monaco 1:0 (0:0)
2nd (2nd leg) AS Monaco - Real Betis 2:2 (1:1)
1st(1st leg): 09/08/2005 21:00 2nd (2nd leg): 23/08/2005 19:45 Winner: Real Betis
1st(1st leg) Malmö FF - FC Thun 0:1 (0:1)
2nd (2nd leg) FC Thun - Malmö FF 3:0 (2:0)
1st(1st leg): 10/08/2005 17:45 2nd (2nd leg): 23/08/2005 19:15 Winner: FC Thun
1st(1st leg) Brøndby IF - AFC Ajax 2:2 (1:1)
2nd (2nd leg) AFC Ajax - Brøndby IF 3:1 (0:1)
1st(1st leg): 10/08/2005 18:00 2nd (2nd leg): 24/08/2005 19:30 Winner: AFC Ajax
1st(1st leg) Shakhtar Donetsk - Inter 0:2 (0:0)
2nd (2nd leg) Inter - Shakhtar Donetsk 1:1 (1:1)
1st(1st leg): 10/08/2005 19:00 2nd (2nd leg): 24/08/2005 20:00 Winner: Inter
1st(1st leg) Artmedia Petržalka - Partizan 0:0 (0:0)
2nd (2nd leg) Partizan - Artmedia Petržalka 3:4 (0:0, 0:0, 0:0) pso
1st(1st leg): 10/08/2005 19:00 2nd (2nd leg): 23/08/2005 19:00 Winner: Artmedia Petržalka
1st(1st leg) FC Steaua Bucureşti - Rosenborg BK 1:1 (1:0)
2nd (2nd leg) Rosenborg BK - FC Steaua Bucureşti 3:2 (1:0)
1st(1st leg): 10/08/2005 19:00 2nd (2nd leg): 23/08/2005 19:45 Winner: Rosenborg BK
1st(1st leg) RSC Anderlecht - Slavia Praha 2:1 (2:1)
2nd (2nd leg) Slavia Praha - RSC Anderlecht 0:2 (0:0)
1st(1st leg): 10/08/2005 19:30 2nd (2nd leg): 24/08/2005 19:05 Winner: RSC Anderlecht
1st(1st leg) FC Basel - Werder Bremen 2:1 (1:0)
2nd (2nd leg) Werder Bremen - FC Basel 3:0 (0:0)
1st(1st leg): 10/08/2005 19:45 2nd (2nd leg): 24/08/2005 19:45 Winner: Werder Bremen
1st(1st leg) Rapid Wien - Lokomotiv Moskva 1:1 (0:1)
2nd (2nd leg) Lokomotiv Moskva - Rapid Wien 0:1 (0:0)
1st(1st leg): 10/08/2005 19:45 2nd (2nd leg): 23/08/2005 16:00 Winner: Rapid Wien
1st(1st leg) CSKA Sofia - Liverpool FC 1:3 (1:2)
2nd (2nd leg) Liverpool FC - CSKA Sofia 0:1 (0:1)
1st(1st leg): 10/08/2005 19:45 2nd (2nd leg): 23/08/2005 20:05 Winner: Liverpool FC
1st(1st leg) Sporting CP - Udinese Calcio 0:1 (0:1)
2nd (2nd leg) Udinese Calcio - Sporting CP 3:2 (2:1)
1st(1st leg): 10/08/2005 21:15 2nd (2nd leg): 23/08/2005 19:45 Winner: Udinese Calcio