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| 1st(1st leg) | FC Porto | - | Spartak Moskva | 5:1 (1:0) | ||
| 2nd (2nd leg) | Spartak Moskva | - | FC Porto | 2:5 (0:2) | ||
| 1st(1st leg): 07/04/2011 20:05 | 2nd (2nd leg): 14/04/2011 18:00 | Winner: FC Porto | ||||
| 1st(1st leg) | SL Benfica | - | PSV Eindhoven | 4:1 (2:0) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | SL Benfica | 2:2 (2:1) | ||
| 1st(1st leg): 07/04/2011 20:05 | 2nd (2nd leg): 14/04/2011 20:05 | Winner: SL Benfica | ||||
| 1st(1st leg) | Villarreal CF | - | FC Twente | 5:1 (3:0) | ||
| 2nd (2nd leg) | FC Twente | - | Villarreal CF | 1:3 (1:0) | ||
| 1st(1st leg): 07/04/2011 20:05 | 2nd (2nd leg): 14/04/2011 20:05 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Dinamo Kiev | - | Sporting Braga | 1:1 (1:1) | ||
| 2nd (2nd leg) | Sporting Braga | - | Dinamo Kiev | 0:0 (0:0) | ||
| 1st(1st leg): 07/04/2011 20:05 | 2nd (2nd leg): 14/04/2011 20:05 | Winner: Sporting Braga | ||||
