1st(1st leg) Rubin Kazan - Olympiakos Piräus 0:1 (0:0)
2nd (2nd leg) Olympiakos Piräus - Rubin Kazan 1:0 (1:0)
1st(1st leg): 14/02/2012 11:00 2nd (2nd leg): 23/02/2012 20:05 Winner: Olympiakos Piräus
1st(1st leg) Sporting Braga - Beşiktaş 0:2 (0:1)
2nd (2nd leg) Beşiktaş - Sporting Braga 0:1 (0:1)
1st(1st leg): 14/02/2012 17:30 2nd (2nd leg): 23/02/2012 20:05 Winner: Beşiktaş
1st(1st leg) Lokomotiv Moskva - Athletic Bilbao 2:1 (0:1)
2nd (2nd leg) Athletic Bilbao - Lokomotiv Moskva 1:0 (0:0)
1st(1st leg): 16/02/2012 17:00 2nd (2nd leg): 23/02/2012 18:00 Winner: Athletic Bilbao
1st(1st leg) AFC Ajax - Manchester United 0:2 (0:0)
2nd (2nd leg) Manchester United - AFC Ajax 1:2 (1:1)
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: Manchester United
1st(1st leg) RB Salzburg - Metalist Kharkov 0:4 (0:3)
2nd (2nd leg) Metalist Kharkov - RB Salzburg 4:1 (1:0)
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: Metalist Kharkov
1st(1st leg) AZ Alkmaar - RSC Anderlecht 1:0 (1:0)
2nd (2nd leg) RSC Anderlecht - AZ Alkmaar 0:1 (0:0)
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: AZ Alkmaar
1st(1st leg) Lazio Roma - Atlético Madrid 1:3 (1:2)
2nd (2nd leg) Atlético Madrid - Lazio Roma 1:0 (0:0)
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: Atlético Madrid
1st(1st leg) Viktoria Plzeň - FC Schalke 04 1:1 (1:0)
2nd (2nd leg) FC Schalke 04 - Viktoria Plzeň 3:1 (1:0, 1:1) aet
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: FC Schalke 04
1st(1st leg) Legia Warszawa - Sporting CP 2:2 (1:0)
2nd (2nd leg) Sporting CP - Legia Warszawa 1:0 (0:0)
1st(1st leg): 16/02/2012 18:00 2nd (2nd leg): 23/02/2012 20:05 Winner: Sporting CP
1st(1st leg) FC Porto - Manchester City 1:2 (1:0)
2nd (2nd leg) Manchester City - FC Porto 4:0 (1:0)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 22/02/2012 17:00 Winner: Manchester City
1st(1st leg) Stoke City - Valencia CF 0:1 (0:1)
2nd (2nd leg) Valencia CF - Stoke City 1:0 (1:0)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: Valencia CF
1st(1st leg) Steaua Bucureşti - FC Twente 0:1 (0:0)
2nd (2nd leg) FC Twente - Steaua Bucureşti 1:0 (1:0)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: FC Twente
1st(1st leg) Wisła Kraków - Standard Liège 1:1 (0:1)
2nd (2nd leg) Standard Liège - Wisła Kraków 0:0 (0:0)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: Standard Liège
1st(1st leg) Udinese Calcio - PAOK Saloniki 0:0 (0:0)
2nd (2nd leg) PAOK Saloniki - Udinese Calcio 0:3 (0:2)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: Udinese Calcio
1st(1st leg) Trabzonspor - PSV Eindhoven 1:2 (1:2)
2nd (2nd leg) PSV Eindhoven - Trabzonspor 4:1 (3:1)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: PSV Eindhoven
1st(1st leg) Hannover 96 - Club Brugge KV 2:1 (0:0)
2nd (2nd leg) Club Brugge KV - Hannover 96 0:1 (0:1)
1st(1st leg): 16/02/2012 20:05 2nd (2nd leg): 23/02/2012 18:00 Winner: Hannover 96