1st(1st leg) Metalist Kharkov - Olympiakos Piräus 0:1 (0:0)
2nd (2nd leg) Olympiakos Piräus - Metalist Kharkov 1:2 (1:0)
1st(1st leg): 08/03/2012 18:00 2nd (2nd leg): 15/03/2012 20:05 Winner: Metalist Kharkov
1st(1st leg) Sporting CP - Manchester City 1:0 (0:0)
2nd (2nd leg) Manchester City - Sporting CP 3:2 (0:2)
1st(1st leg): 08/03/2012 18:00 2nd (2nd leg): 15/03/2012 20:05 Winner: Sporting CP
1st(1st leg) FC Twente - FC Schalke 04 1:0 (0:0)
2nd (2nd leg) FC Schalke 04 - FC Twente 4:1 (1:1)
1st(1st leg): 08/03/2012 18:00 2nd (2nd leg): 15/03/2012 20:05 Winner: FC Schalke 04
1st(1st leg) Atlético Madrid - Beşiktaş 3:1 (3:0)
2nd (2nd leg) Beşiktaş - Atlético Madrid 0:3 (0:1)
1st(1st leg): 08/03/2012 18:00 2nd (2nd leg): 15/03/2012 20:05 Winner: Atlético Madrid
1st(1st leg) Standard Liège - Hannover 96 2:2 (2:1)
2nd (2nd leg) Hannover 96 - Standard Liège 4:0 (2:0)
1st(1st leg): 08/03/2012 20:05 2nd (2nd leg): 15/03/2012 18:00 Winner: Hannover 96
1st(1st leg) Valencia CF - PSV Eindhoven 4:2 (3:0)
2nd (2nd leg) PSV Eindhoven - Valencia CF 1:1 (0:0)
1st(1st leg): 08/03/2012 20:05 2nd (2nd leg): 15/03/2012 18:00 Winner: Valencia CF
1st(1st leg) AZ Alkmaar - Udinese Calcio 2:0 (0:0)
2nd (2nd leg) Udinese Calcio - AZ Alkmaar 2:1 (2:1)
1st(1st leg): 08/03/2012 20:05 2nd (2nd leg): 15/03/2012 18:00 Winner: AZ Alkmaar
1st(1st leg) Manchester United - Athletic Bilbao 2:3 (1:1)
2nd (2nd leg) Athletic Bilbao - Manchester United 2:1 (1:0)
1st(1st leg): 08/03/2012 20:05 2nd (2nd leg): 15/03/2012 18:00 Winner: Athletic Bilbao