1st(1st leg) AFC Ajax - BSC Young Boys 3:0 (0:0)
2nd (2nd leg) BSC Young Boys - AFC Ajax 0:2 (0:1)
1st(1st leg): 11/03/2021 17:55 2nd (2nd leg): 18/03/2021 20:00 Winner: AFC Ajax
1st(1st leg) Dinamo Kiev - Villarreal CF 0:2 (0:1)
2nd (2nd leg) Villarreal CF - Dinamo Kiev 2:0 (2:0)
1st(1st leg): 11/03/2021 17:55 2nd (2nd leg): 18/03/2021 20:00 Winner: Villarreal CF
1st(1st leg) Manchester United - AC Milan 1:1 (0:0)
2nd (2nd leg) AC Milan - Manchester United 0:1 (0:0)
1st(1st leg): 11/03/2021 17:55 2nd (2nd leg): 18/03/2021 20:00 Winner: Manchester United
1st(1st leg) Slavia Praha - Rangers FC 1:1 (1:1)
2nd (2nd leg) Rangers FC - Slavia Praha 0:2 (0:1)
1st(1st leg): 11/03/2021 17:55 2nd (2nd leg): 18/03/2021 20:00 Winner: Slavia Praha
1st(1st leg) AS Roma - Shakhtar Donetsk 3:0 (1:0)
2nd (2nd leg) Shakhtar Donetsk - AS Roma 1:2 (0:0)
1st(1st leg): 11/03/2021 20:00 2nd (2nd leg): 18/03/2021 17:55 Winner: AS Roma
1st(1st leg) Olympiakos Piräus - Arsenal FC 1:3 (0:1)
2nd (2nd leg) Arsenal FC - Olympiakos Piräus 0:1 (0:0)
1st(1st leg): 11/03/2021 20:00 2nd (2nd leg): 18/03/2021 17:55 Winner: Arsenal FC
1st(1st leg) Tottenham Hotspur - Dinamo Zagreb 2:0 (1:0)
2nd (2nd leg) Dinamo Zagreb - Tottenham Hotspur 3:0 (0:0, 2:0, 3:0) aet
1st(1st leg): 11/03/2021 20:00 2nd (2nd leg): 18/03/2021 17:55 Winner: Dinamo Zagreb
1st(1st leg) Granada CF - Molde FK 2:0 (1:0)
2nd (2nd leg) Molde FK - Granada CF 2:1 (1:0)
1st(1st leg): 11/03/2021 20:00 2nd (2nd leg): 18/03/2021 17:55 Winner: Granada CF