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| 1st(1st leg) | AFC Ajax | - | BSC Young Boys | 3:0 (0:0) | ||
| 2nd (2nd leg) | BSC Young Boys | - | AFC Ajax | 0:2 (0:1) | ||
| 1st(1st leg): 11/03/2021 17:55 | 2nd (2nd leg): 18/03/2021 20:00 | Winner: AFC Ajax | ||||
| 1st(1st leg) | Dinamo Kiev | - | Villarreal CF | 0:2 (0:1) | ||
| 2nd (2nd leg) | Villarreal CF | - | Dinamo Kiev | 2:0 (2:0) | ||
| 1st(1st leg): 11/03/2021 17:55 | 2nd (2nd leg): 18/03/2021 20:00 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Manchester United | - | AC Milan | 1:1 (0:0) | ||
| 2nd (2nd leg) | AC Milan | - | Manchester United | 0:1 (0:0) | ||
| 1st(1st leg): 11/03/2021 17:55 | 2nd (2nd leg): 18/03/2021 20:00 | Winner: Manchester United | ||||
| 1st(1st leg) | Slavia Praha | - | Rangers FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Rangers FC | - | Slavia Praha | 0:2 (0:1) | ||
| 1st(1st leg): 11/03/2021 17:55 | 2nd (2nd leg): 18/03/2021 20:00 | Winner: Slavia Praha | ||||
| 1st(1st leg) | AS Roma | - | Shakhtar Donetsk | 3:0 (1:0) | ||
| 2nd (2nd leg) | Shakhtar Donetsk | - | AS Roma | 1:2 (0:0) | ||
| 1st(1st leg): 11/03/2021 20:00 | 2nd (2nd leg): 18/03/2021 17:55 | Winner: AS Roma | ||||
| 1st(1st leg) | Olympiakos Piraeus | - | Arsenal FC | 1:3 (0:1) | ||
| 2nd (2nd leg) | Arsenal FC | - | Olympiakos Piraeus | 0:1 (0:0) | ||
| 1st(1st leg): 11/03/2021 20:00 | 2nd (2nd leg): 18/03/2021 17:55 | Winner: Arsenal FC | ||||
| 1st(1st leg) | Tottenham Hotspur | - | Dinamo Zagreb | 2:0 (1:0) | ||
| 2nd (2nd leg) | Dinamo Zagreb | - | Tottenham Hotspur | 3:0 (0:0, 2:0, 3:0) aet | ||
| 1st(1st leg): 11/03/2021 20:00 | 2nd (2nd leg): 18/03/2021 17:55 | Winner: Dinamo Zagreb | ||||
| 1st(1st leg) | Granada CF | - | Molde FK | 2:0 (1:0) | ||
| 2nd (2nd leg) | Molde FK | - | Granada CF | 2:1 (1:0) | ||
| 1st(1st leg): 11/03/2021 20:00 | 2nd (2nd leg): 18/03/2021 17:55 | Winner: Granada CF | ||||
