1st(1st leg) Gabala FK - Panathinaikos 0:0 (0:0)
2nd (2nd leg) Panathinaikos - Gabala FK 2:2 (1:1)
1st(1st leg): 20/08/2015 17:00 2nd (2nd leg): 27/08/2015 19:00 Winner: Gabala FK
1st(1st leg) Astra Giurgiu - AZ Alkmaar 3:2 (3:2)
2nd (2nd leg) AZ Alkmaar - Astra Giurgiu 2:0 (0:0)
1st(1st leg): 20/08/2015 17:00 2nd (2nd leg): 27/08/2015 19:00 Winner: AZ Alkmaar
1st(1st leg) Dinamo Minsk - RB Salzburg 2:0 (0:0)
2nd (2nd leg) RB Salzburg - Dinamo Minsk 2:3 (1:0, 2:0, 2:0) pso
1st(1st leg): 20/08/2015 17:00 2nd (2nd leg): 27/08/2015 19:30 Winner: Dinamo Minsk
1st(1st leg) AFC Ajax - FK Jablonec 1:0 (0:0)
2nd (2nd leg) FK Jablonec - AFC Ajax 0:0 (0:0)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 17:00 Winner: AFC Ajax
1st(1st leg) Molde FK - Standard Liège 2:0 (2:0)
2nd (2nd leg) Standard Liège - Molde FK 3:1 (1:1)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 19:30 Winner: Molde FK
1st(1st leg) Zorya Lugansk - Legia Warszawa 0:1 (0:0)
2nd (2nd leg) Legia Warszawa - Zorya Lugansk 3:2 (1:1)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 20:00 Winner: Legia Warszawa
1st(1st leg) PAOK Saloniki - Brøndby IF 5:0 (2:0)
2nd (2nd leg) Brøndby IF - PAOK Saloniki 1:1 (1:1)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 19:00 Winner: PAOK Saloniki
1st(1st leg) Slovan Liberec - Hajduk Split 1:0 (0:0)
2nd (2nd leg) Hajduk Split - Slovan Liberec 0:1 (0:1)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 19:00 Winner: Slovan Liberec
1st(1st leg) FK Krasnodar - HJK Helsinki 5:1 (2:1)
2nd (2nd leg) HJK Helsinki - FK Krasnodar 0:0 (0:0)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 18:00 Winner: FK Krasnodar
1st(1st leg) Sparta Praha - FC Thun 3:1 (2:1)
2nd (2nd leg) FC Thun - Sparta Praha 3:3 (1:2)
1st(1st leg): 20/08/2015 18:00 2nd (2nd leg): 27/08/2015 18:30 Winner: Sparta Praha
1st(1st leg) FC Milsami - AS Saint-Étienne 1:1 (0:1)
2nd (2nd leg) AS Saint-Étienne - FC Milsami 1:0 (1:0)
1st(1st leg): 20/08/2015 18:30 2nd (2nd leg): 27/08/2015 18:30 Winner: AS Saint-Étienne
1st(1st leg) FC Steaua Bucureşti - Rosenborg BK 0:3 (0:0)
2nd (2nd leg) Rosenborg BK - FC Steaua Bucureşti 0:1 (0:0)
1st(1st leg): 20/08/2015 19:00 2nd (2nd leg): 27/08/2015 19:00 Winner: Rosenborg BK
1st(1st leg) BSC Young Boys - Qarabağ FK 0:1 (0:0)
2nd (2nd leg) Qarabağ FK - BSC Young Boys 3:0 (2:0)
1st(1st leg): 20/08/2015 19:00 2nd (2nd leg): 27/08/2015 17:00 Winner: Qarabağ FK
1st(1st leg) FK Rabotnički - Rubin Kazan 1:1 (0:0)
2nd (2nd leg) Rubin Kazan - FK Rabotnički 1:0 (1:0)
1st(1st leg): 20/08/2015 19:00 2nd (2nd leg): 27/08/2015 17:00 Winner: Rubin Kazan
1st(1st leg) Atromitos - Fenerbahçe 0:1 (0:0)
2nd (2nd leg) Fenerbahçe - Atromitos 3:0 (1:0)
1st(1st leg): 20/08/2015 19:00 2nd (2nd leg): 27/08/2015 19:00 Winner: Fenerbahçe
1st(1st leg) MŠK Žilina - Athletic Bilbao 3:2 (0:2)
2nd (2nd leg) Athletic Bilbao - MŠK Žilina 1:0 (1:0)
1st(1st leg): 20/08/2015 19:15 2nd (2nd leg): 27/08/2015 19:45 Winner: Athletic Bilbao
1st(1st leg) SCR Altach - Os Belenenses 0:1 (0:1)
2nd (2nd leg) Os Belenenses - SCR Altach 0:0 (0:0)
1st(1st leg): 20/08/2015 19:30 2nd (2nd leg): 27/08/2015 21:30 Winner: Os Belenenses
1st(1st leg) Girondins Bordeaux - FK Kairat 1:0 (1:0)
2nd (2nd leg) FK Kairat - Girondins Bordeaux 2:1 (1:0)
1st(1st leg): 20/08/2015 19:30 2nd (2nd leg): 27/08/2015 15:45 Winner: Girondins Bordeaux
1st(1st leg) Odds BK - Borussia Dortmund 3:4 (3:1)
2nd (2nd leg) Borussia Dortmund - Odds BK 7:2 (4:1)
1st(1st leg): 20/08/2015 19:30 2nd (2nd leg): 27/08/2015 19:30 Winner: Borussia Dortmund
1st(1st leg) Viktoria Plzeň - Vojvodina 3:0 (1:0)
2nd (2nd leg) Vojvodina - Viktoria Plzeň 0:2 (0:1)
1st(1st leg): 20/08/2015 19:50 2nd (2nd leg): 27/08/2015 19:30 Winner: Viktoria Plzeň
1st(1st leg) Lech Poznań - Videoton FC 3:0 (1:0)
2nd (2nd leg) Videoton FC - Lech Poznań 0:1 (0:0)
1st(1st leg): 20/08/2015 20:00 2nd (2nd leg): 27/08/2015 18:00 Winner: Lech Poznań
1st(1st leg) Southampton FC - FC Midtjylland 1:1 (0:1)
2nd (2nd leg) FC Midtjylland - Southampton FC 1:0 (1:0)
1st(1st leg): 20/08/2015 20:00 2nd (2nd leg): 27/08/2015 19:45 Winner: FC Midtjylland