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| 28/09/2021 | 17:30 | Rot-Weiß Koblenz | - | FC-Astoria Walldorf | 2:2 (0:1) | |
| 18:00 | FC 08 Homburg | - | Bahlinger SC | 1:0 (0:0) | ||
| 18:00 | Kickers Offenbach | - | TSV Schott Mainz | 0:1 (0:0) | ||
| 18:00 | SG Sonnenhof Großaspach | - | FC Gießen | 1:1 (0:0) | ||
| 18:00 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 0:2 (0:1) | ||
| 18:00 | SV 07 Elversberg | - | FK Pirmasens | 1:0 (1:0) | ||
| 18:00 | 1899 Hoffenheim II | - | Hessen Kassel | 2:0 (1:0) | ||
| 18:00 | VfB Stuttgart II | - | VfR Aalen | 1:2 (1:1) | ||
| 29/09/2021 | 18:00 | FSV Frankfurt | - | TSG Balingen | 4:0 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FSV Mainz 05 II | 10 | 7 | 0 | 3 | 18:15 | 3 | 21 |
| 2 |
|
TSV Steinbach Haiger | 9 | 6 | 2 | 1 | 15:8 | 7 | 20 |
| 3 |
|
Bahlinger SC | 9 | 6 | 1 | 2 | 11:7 | 4 | 19 |
| 4 |
|
SSV Ulm 1846 | 9 | 5 | 3 | 1 | 20:16 | 4 | 18 |
| 5 |
|
SV 07 Elversberg | 9 | 5 | 2 | 2 | 20:11 | 9 | 17 |
| 6 |
|
FC 08 Homburg | 10 | 5 | 2 | 3 | 14:17 | -3 | 17 |
| 7 |
|
VfB Stuttgart II | 10 | 5 | 0 | 5 | 23:19 | 4 | 15 |
| 8 |
|
1899 Hoffenheim II | 9 | 4 | 2 | 3 | 16:11 | 5 | 14 |
| 9 |
|
SG Sonnenhof Großaspach | 10 | 4 | 2 | 4 | 17:15 | 2 | 14 |
| 10 |
|
Kickers Offenbach | 9 | 4 | 2 | 3 | 8:7 | 1 | 14 |
| 11 |
|
VfR Aalen | 9 | 4 | 0 | 5 | 13:14 | -1 | 12 |
| 12 |
|
Hessen Kassel | 10 | 3 | 3 | 4 | 11:12 | -1 | 12 |
| 13 |
|
FSV Frankfurt | 10 | 3 | 2 | 5 | 14:14 | 0 | 11 |
| 14 |
|
FK Pirmasens | 10 | 3 | 2 | 5 | 10:13 | -3 | 11 |
| 15 |
|
FC-Astoria Walldorf | 10 | 2 | 3 | 5 | 12:19 | -7 | 9 |
| 16 |
|
TSV Schott Mainz | 10 | 2 | 2 | 6 | 11:17 | -6 | 8 |
| 17 |
|
Rot-Weiß Koblenz | 9 | 2 | 2 | 5 | 9:15 | -6 | 8 |
| 18 |
|
FC Gießen | 9 | 2 | 1 | 6 | 6:11 | -5 | 7 |
| 19 |
|
TSG Balingen | 9 | 2 | 1 | 6 | 11:18 | -7 | 7 |
| Promotion | |
| Relegation |
