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| 02/10/2021 | 13:00 | Bahlinger SC | - | SV 07 Elversberg | 0:1 (0:0) | |
| 13:00 | FC-Astoria Walldorf | - | 1899 Hoffenheim II | 2:5 (1:0) | ||
| 13:00 | FC Gießen | - | VfB Stuttgart II | 2:1 (2:0) | ||
| 13:00 | FK Pirmasens | - | Kickers Offenbach | 0:2 (0:1) | ||
| 13:00 | 1. FSV Mainz 05 II | - | Rot-Weiß Koblenz | 2:1 (1:1) | ||
| 13:00 | TSG Balingen | - | FC 08 Homburg | 2:1 (0:1) | ||
| 13:00 | TSV Schott Mainz | - | SSV Ulm 1846 | 0:1 (0:0) | ||
| 13:00 | TSV Steinbach Haiger | - | SG Sonnenhof Großaspach | 3:0 (2:0) | ||
| 13:00 | VfR Aalen | - | FSV Frankfurt | 1:0 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FSV Mainz 05 II | 11 | 8 | 0 | 3 | 20:16 | 4 | 24 |
| 2 |
|
TSV Steinbach Haiger | 10 | 7 | 2 | 1 | 18:8 | 10 | 23 |
| 3 |
|
SSV Ulm 1846 | 10 | 6 | 3 | 1 | 21:16 | 5 | 21 |
| 4 |
|
SV 07 Elversberg | 10 | 6 | 2 | 2 | 21:11 | 10 | 20 |
| 5 |
|
Bahlinger SC | 10 | 6 | 1 | 3 | 11:8 | 3 | 19 |
| 6 |
|
1899 Hoffenheim II | 10 | 5 | 2 | 3 | 21:13 | 8 | 17 |
| 7 |
|
Kickers Offenbach | 10 | 5 | 2 | 3 | 10:7 | 3 | 17 |
| 8 |
|
FC 08 Homburg | 11 | 5 | 2 | 4 | 15:19 | -4 | 17 |
| 9 |
|
VfB Stuttgart II | 11 | 5 | 0 | 6 | 24:21 | 3 | 15 |
| 10 |
|
VfR Aalen | 10 | 5 | 0 | 5 | 14:14 | 0 | 15 |
| 11 |
|
SG Sonnenhof Großaspach | 11 | 4 | 2 | 5 | 17:18 | -1 | 14 |
| 12 |
|
Hessen Kassel | 10 | 3 | 3 | 4 | 11:12 | -1 | 12 |
| 13 |
|
FSV Frankfurt | 11 | 3 | 2 | 6 | 14:15 | -1 | 11 |
| 14 |
|
FK Pirmasens | 11 | 3 | 2 | 6 | 10:15 | -5 | 11 |
| 15 |
|
FC Gießen | 10 | 3 | 1 | 6 | 8:12 | -4 | 10 |
| 16 |
|
TSG Balingen | 10 | 3 | 1 | 6 | 13:19 | -6 | 10 |
| 17 |
|
FC-Astoria Walldorf | 11 | 2 | 3 | 6 | 14:24 | -10 | 9 |
| 18 |
|
TSV Schott Mainz | 11 | 2 | 2 | 7 | 11:18 | -7 | 8 |
| 19 |
|
Rot-Weiß Koblenz | 10 | 2 | 2 | 6 | 10:17 | -7 | 8 |
| Promotion | |
| Relegation |
