1st(1st leg) IF Elfsborg - FK Rīga 1:0 (1:0)
2nd (2nd leg) FK Rīga - IF Elfsborg 0:0 (0:0)
1st(1st leg): 19/07/2008 14:30 2nd (2nd leg): 27/07/2008 16:00 Winner: IF Elfsborg
1st(1st leg) FK Saturn - VfB Stuttgart 1:0 (1:0)
2nd (2nd leg) VfB Stuttgart - FK Saturn 3:0 (0:0, 1:0) aet
1st(1st leg): 19/07/2008 15:00 2nd (2nd leg): 27/07/2008 17:00 Winner: VfB Stuttgart
1st(1st leg) Grasshopper Club Zürich - PSFC Chernomorets 3:0 (2:0)
2nd (2nd leg) PSFC Chernomorets - Grasshopper Club Zürich 0:1 (0:0)
1st(1st leg): 19/07/2008 16:45 2nd (2nd leg): 26/07/2008 18:45 Winner: Grasshopper Club Zürich
1st(1st leg) Neftçi PFK - FC Vaslui 2:1 (1:1)
2nd (2nd leg) FC Vaslui - Neftçi PFK 2:0 (2:0)
1st(1st leg): 19/07/2008 17:00 2nd (2nd leg): 26/07/2008 18:30 Winner: FC Vaslui
1st(1st leg) Sturm Graz - Budapest Honvéd 0:0 (0:0)
2nd (2nd leg) Budapest Honvéd - Sturm Graz 1:2 (1:0)
1st(1st leg): 19/07/2008 17:00 2nd (2nd leg): 26/07/2008 19:00 Winner: Sturm Graz
1st(1st leg) Bnei Sachnin FC - Deportivo La Coruña 1:2 (0:0)
2nd (2nd leg) Deportivo La Coruña - Bnei Sachnin FC 1:0 (1:0)
1st(1st leg): 19/07/2008 18:00 2nd (2nd leg): 26/07/2008 20:00 Winner: Deportivo La Coruña
1st(1st leg) Stade Rennes - Tavriya Simferopol (alt) 1:0 (0:0)
2nd (2nd leg) Tavriya Simferopol (alt) - Stade Rennes 9:10 (0:0, 1:0, 1:0) pso
1st(1st leg): 19/07/2008 18:00 2nd (2nd leg): 26/07/2008 17:00 Winner: Stade Rennes
1st(1st leg) NAC Breda - Rosenborg BK 1:0 (1:0)
2nd (2nd leg) Rosenborg BK - NAC Breda 2:0 (1:0)
1st(1st leg): 19/07/2008 18:30 2nd (2nd leg): 27/07/2008 14:45 Winner: Rosenborg BK
1st(1st leg) Odense BK - Aston Villa 2:2 (1:1)
2nd (2nd leg) Aston Villa - Odense BK 1:0 (0:0)
1st(1st leg): 19/07/2008 19:05 2nd (2nd leg): 26/07/2008 17:15 Winner: Aston Villa
1st(1st leg) Panionios GSS - SSC Napoli 0:1 (0:1)
2nd (2nd leg) SSC Napoli - Panionios GSS 1:0 (0:0)
1st(1st leg): 20/07/2008 17:00 2nd (2nd leg): 26/07/2008 20:00 Winner: SSC Napoli
1st(1st leg) Sivasspor - Sporting Braga 0:2 (0:1)
2nd (2nd leg) Sporting Braga - Sivasspor 3:0 (1:0)
1st(1st leg): 20/07/2008 17:00 2nd (2nd leg): 26/07/2008 19:00 Winner: Sporting Braga