2. Round | 21/08/2021 | Sportfreunde Lotte | - | VfB Homberg | 2:0 | ||||
3. Round | 25/08/2021 | Preußen Münster | - | Sportfreunde Lotte | 2:0 | ||||
4. Round | 28/08/2021 | Sportfreunde Lotte | - | FC Schalke 04 II | 2:0 | ||||
5. Round | 04/09/2021 | SV Lippstadt 08 | - | Sportfreunde Lotte | 2:1 | ||||
11. Round | 09/10/2021 | Bor. Mönchengladbach II | - | Sportfreunde Lotte | 3:0 | ||||
14. Round | 30/10/2021 | SV Rödinghausen | - | Sportfreunde Lotte | 3:0 | ||||
20. Round | 14/12/2021 | Sportfreunde Lotte | - | Fortuna Düsseldorf II | 3:1 |