| 1. Round | 14/08/2021 | Rot-Weiß Oberhausen | - | KFC Uerdingen 05 | 6:0 | ||||
| 3. Round | 25/08/2021 | KFC Uerdingen 05 | - | SC Wiedenbrück | 2:3 | ||||
| 4. Round | 28/08/2021 | 1. FC Köln II | - | KFC Uerdingen 05 | 8:2 | ||||
| 5. Round | 04/09/2021 | KFC Uerdingen 05 | - | Alemannia Aachen | 0:0 |  |
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| 7. Round | 06/10/2021 | KFC Uerdingen 05 | - | Sportfreunde Lotte | 2:0 | ||||
| 11. Round | 09/10/2021 | KFC Uerdingen 05 | - | Rot-Weiss Essen | 0:11 | ||||
| 12. Round | 16/10/2021 | SV 19 Straelen | - | KFC Uerdingen 05 | 2:0 | |
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| 13. Round | 23/10/2021 | KFC Uerdingen 05 | - | Wuppertaler SV | 0:2 | ||||
| 14. Round | 30/10/2021 | Fortuna Köln | - | KFC Uerdingen 05 | 4:0 | ||||
| 15. Round | 06/11/2021 | KFC Uerdingen 05 | - | Fortuna Düsseldorf II | 1:1 | ||||
| 16. Round | 13/11/2021 | VfB Homberg | - | KFC Uerdingen 05 | 1:1 | ||||
| 17. Round | 20/11/2021 | KFC Uerdingen 05 | - | Preußen Münster | 0:1 | ||||
| 18. Round | 26/11/2021 | FC Schalke 04 II | - | KFC Uerdingen 05 | 4:1 | ||||
| 20. Round | 11/12/2021 | KFC Uerdingen 05 | - | Rot-Weiß Oberhausen | 2:5 |
Germany