| 1. Round | 14/08/2021 | Bonner SC | - | Rot-Weiss Essen | 0:3 |  |
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| 2. Round | 21/08/2021 | KFC Uerdingen 05 | - | Bonner SC | 1:3 | ||||
| 7. Round | 15/09/2021 | Bonner SC | - | Fortuna Köln | 0:2 | |
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| 8. Round | 19/09/2021 | Bonner SC | - | Alemannia Aachen | 1:1 | ||||
| 9. Round | 25/09/2021 | Bonner SC | - | Fortuna Düsseldorf II | 0:3 | |
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| 10. Round | 02/10/2021 | Bor. Mönchengladbach II | - | Bonner SC | 2:1 | ||||
| 17. Round | 20/11/2021 | Bonner SC | - | SV Lippstadt 08 | 0:1 | ||||
| 18. Round | 27/11/2021 | Bonner SC | - | Rot Weiss Ahlen | 2:2 | ||||
| 22. Round | 22/01/2022 | SV 19 Straelen | - | Bonner SC | 0:0 | |
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| 23. Round | 29/01/2022 | Bonner SC | - | SC Wiedenbrück | 0:0 | ||||
| 25. Round | 12/02/2022 | Bonner SC | - | 1. FC Köln II | 1:3 |  |
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| 27. Round | 26/02/2022 | Alemannia Aachen | - | Bonner SC | 0:0 | |
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| 28. Round | 05/03/2022 | Fortuna Düsseldorf II | - | Bonner SC | 1:2 | ||||
| 31. Round | 26/03/2022 | Bonner SC | - | Sportfreunde Lotte | 0:2 | |
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| 32. Round | 02/04/2022 | Preußen Münster | - | Bonner SC | 3:0 | ||||
| 33. Round | 09/04/2022 | Bonner SC | - | FC Wegberg-Beeck | 2:0 | ||||
| 34. Round | 16/04/2022 | FC Schalke 04 II | - | Bonner SC | 1:0 |
Germany