| 1. Round | 14/08/2021 | FK Pirmasens | - | Bahlinger SC | 0:0 | ||||
| 2. Round | 21/08/2021 | TSG Balingen | - | FK Pirmasens | 1:2 |  |
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| 5. Round | 04/09/2021 | FK Pirmasens | - | TSV Steinbach Haiger | 1:2 |  |
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| 6. Round | 12/09/2021 | SG Sonnenhof Großaspach | - | FK Pirmasens | 3:1 | ||||
| 7. Round | 15/09/2021 | FK Pirmasens | - | VfB Stuttgart II | 2:3 | |
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| 8. Round | 18/09/2021 | FSV Frankfurt | - | FK Pirmasens | 2:2 | |
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| 10. Round | 28/09/2021 | SV 07 Elversberg | - | FK Pirmasens | 1:0 | ||||
| 11. Round | 02/10/2021 | FK Pirmasens | - | Kickers Offenbach | 0:2 | ||||
| 12. Round | 09/10/2021 | SSV Ulm 1846 | - | FK Pirmasens | 3:0 | ||||
| 13. Round | 16/10/2021 | FK Pirmasens | - | Rot-Weiß Koblenz | 0:0 | ||||
| 14. Round | 22/10/2021 | 1899 Hoffenheim II | - | FK Pirmasens | 0:2 | ||||
| 15. Round | 26/10/2021 | FK Pirmasens | - | Hessen Kassel | 1:2 | ||||
| 16. Round | 30/10/2021 | FC-Astoria Walldorf | - | FK Pirmasens | 3:1 | |
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| 17. Round | 06/11/2021 | FK Pirmasens | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 18. Round | 13/11/2021 | TSV Schott Mainz | - | FK Pirmasens | 0:1 | |
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| 22. Round | 11/12/2021 | VfR Aalen | - | FK Pirmasens | 2:2 | ||||
| 23. Round | 18/12/2021 | FK Pirmasens | - | FC Gießen | 2:1 |
Germany